Abstract
PYRIDOXINE, the major dietary form of vitamin B6, is rapidly converted in the body to pyridoxal phosphate (pyridoxal-P), the coenzyme form. Pyridoxine has been shown to be phosphorylated in liver and brain homogenates1 and in red cells2, and is subsequently oxidised to pyridoxal-P. In the red cell pyridoxal-P is dephosphorylated, and pyridoxal is the form that is then released into plasma2. But the endogenous form of B6 found in plasma is mainly pyridoxal-P. This paper reports our findings on the ability of plasma proteins to bind these two circulating forms-pyridoxal and pyridoxal-P, and their dietary precursor, pyridoxine. We found that there were marked differences in the extent to which each B6 compound was bound. These findings can be interpreted to explain part of the mechanism which regulates the passage of B6 compounds into and out of the red cell.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 502-504 |
| Number of pages | 3 |
| Journal | Nature |
| Volume | 250 |
| Issue number | 5466 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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Plasma binding of vitamin B6 compounds. / Anderson, B. B.; Newmark, P. A.; Rawlins, M.; Green, Ralph.
In: Nature, Vol. 250, No. 5466, 1974, p. 502-504.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma binding of vitamin B6 compounds
AU - Anderson, B. B.
AU - Newmark, P. A.
AU - Rawlins, M.
AU - Green, Ralph
PY - 1974
Y1 - 1974
N2 - PYRIDOXINE, the major dietary form of vitamin B6, is rapidly converted in the body to pyridoxal phosphate (pyridoxal-P), the coenzyme form. Pyridoxine has been shown to be phosphorylated in liver and brain homogenates1 and in red cells2, and is subsequently oxidised to pyridoxal-P. In the red cell pyridoxal-P is dephosphorylated, and pyridoxal is the form that is then released into plasma2. But the endogenous form of B6 found in plasma is mainly pyridoxal-P. This paper reports our findings on the ability of plasma proteins to bind these two circulating forms-pyridoxal and pyridoxal-P, and their dietary precursor, pyridoxine. We found that there were marked differences in the extent to which each B6 compound was bound. These findings can be interpreted to explain part of the mechanism which regulates the passage of B6 compounds into and out of the red cell.
AB - PYRIDOXINE, the major dietary form of vitamin B6, is rapidly converted in the body to pyridoxal phosphate (pyridoxal-P), the coenzyme form. Pyridoxine has been shown to be phosphorylated in liver and brain homogenates1 and in red cells2, and is subsequently oxidised to pyridoxal-P. In the red cell pyridoxal-P is dephosphorylated, and pyridoxal is the form that is then released into plasma2. But the endogenous form of B6 found in plasma is mainly pyridoxal-P. This paper reports our findings on the ability of plasma proteins to bind these two circulating forms-pyridoxal and pyridoxal-P, and their dietary precursor, pyridoxine. We found that there were marked differences in the extent to which each B6 compound was bound. These findings can be interpreted to explain part of the mechanism which regulates the passage of B6 compounds into and out of the red cell.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016330777&partnerID=8YFLogxK
U2 - 10.1038/250502a0
DO - 10.1038/250502a0
M3 - Article
C2 - 4469603
AN - SCOPUS:0016330777
VL - 250
SP - 502
EP - 504
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5466
ER -