Plasma amino acid profiles in cats with naturally acquired chronic renal failure

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective - To characterize potential changes in preprandial plasma amino acid concentrations in cats with naturally acquired chronic renal failure (CRF), compared with healthy cats, and to assess potential effects of the severity of renal failure on plasma amino acid concentrations in these cats. Animals - 62 adult cats. Procedure - Preprandial plasma amino acid concentrations were evaluated in 38 cats with mild, moderate, or severe CRF and in 24 apparently healthy cats. Effects of severity of renal failure, amount of dietary protein, degree of weight loss, appetite, and body condition on plasma amino acid profiles were evaluated. Results - Cats with various stages of CRF had significantly (P < 0.05) decreased plasma concentrations of o-hydroxyproline, glutamate, proline, glycine, alanine, tyrosine, tryptophan, and arginine, and significantly increased plasma concentrations of asparagine, citrulline, ornithine, 1-methylhistidine, and 3-methylhistidine. Significant (P < 0.05) alterations in amino acid concentrations also were identified when cats with CRF were grouped by appetite or severity of renal disease. Amount of dietary protein, body condition, or degree of weight loss had no significant effect on plasma amino acid concentrations. Conclusions - Compared with those in healthy cats, preprandial plasma amino acid profiles in cats with mild, moderate, or severe CRF are abnormal. Clinical Relevance - Despite frequency of altered plasma amino acid concentrations in cats with CRF, the magnitude of these changes is mild and of little clinical relevance. Short-term use of a commercial protein-restricted diet has no deleterious effects on plasma amino acid concentrations. (Am J Vet Res 1999;60:109-113).

Original languageEnglish (US)
Pages (from-to)109-113
Number of pages5
JournalAmerican Journal of Veterinary Research
Volume60
Issue number1
StatePublished - Jan 1999

Fingerprint

renal failure
Chronic Kidney Failure
Cats
cats
Amino Acids
amino acids
Dietary Proteins
Appetite
glycyl-prolyl-glutamic acid
dietary protein
Renal Insufficiency
body condition
Weight Loss
weight loss
citrulline
Citrulline
Protein-Restricted Diet
protein bodies
Ornithine
ornithine

ASJC Scopus subject areas

  • veterinary(all)

Cite this

@article{3b1e6c74ef5845628cfe44685fc9a640,
title = "Plasma amino acid profiles in cats with naturally acquired chronic renal failure",
abstract = "Objective - To characterize potential changes in preprandial plasma amino acid concentrations in cats with naturally acquired chronic renal failure (CRF), compared with healthy cats, and to assess potential effects of the severity of renal failure on plasma amino acid concentrations in these cats. Animals - 62 adult cats. Procedure - Preprandial plasma amino acid concentrations were evaluated in 38 cats with mild, moderate, or severe CRF and in 24 apparently healthy cats. Effects of severity of renal failure, amount of dietary protein, degree of weight loss, appetite, and body condition on plasma amino acid profiles were evaluated. Results - Cats with various stages of CRF had significantly (P < 0.05) decreased plasma concentrations of o-hydroxyproline, glutamate, proline, glycine, alanine, tyrosine, tryptophan, and arginine, and significantly increased plasma concentrations of asparagine, citrulline, ornithine, 1-methylhistidine, and 3-methylhistidine. Significant (P < 0.05) alterations in amino acid concentrations also were identified when cats with CRF were grouped by appetite or severity of renal disease. Amount of dietary protein, body condition, or degree of weight loss had no significant effect on plasma amino acid concentrations. Conclusions - Compared with those in healthy cats, preprandial plasma amino acid profiles in cats with mild, moderate, or severe CRF are abnormal. Clinical Relevance - Despite frequency of altered plasma amino acid concentrations in cats with CRF, the magnitude of these changes is mild and of little clinical relevance. Short-term use of a commercial protein-restricted diet has no deleterious effects on plasma amino acid concentrations. (Am J Vet Res 1999;60:109-113).",
author = "Goldstein, {Richard E.} and Marks, {Stanley L} and Cowgill, {Larry D} and Kass, {Philip H} and Quinton Rogers",
year = "1999",
month = "1",
language = "English (US)",
volume = "60",
pages = "109--113",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "1",

}

TY - JOUR

T1 - Plasma amino acid profiles in cats with naturally acquired chronic renal failure

AU - Goldstein, Richard E.

AU - Marks, Stanley L

AU - Cowgill, Larry D

AU - Kass, Philip H

AU - Rogers, Quinton

PY - 1999/1

Y1 - 1999/1

N2 - Objective - To characterize potential changes in preprandial plasma amino acid concentrations in cats with naturally acquired chronic renal failure (CRF), compared with healthy cats, and to assess potential effects of the severity of renal failure on plasma amino acid concentrations in these cats. Animals - 62 adult cats. Procedure - Preprandial plasma amino acid concentrations were evaluated in 38 cats with mild, moderate, or severe CRF and in 24 apparently healthy cats. Effects of severity of renal failure, amount of dietary protein, degree of weight loss, appetite, and body condition on plasma amino acid profiles were evaluated. Results - Cats with various stages of CRF had significantly (P < 0.05) decreased plasma concentrations of o-hydroxyproline, glutamate, proline, glycine, alanine, tyrosine, tryptophan, and arginine, and significantly increased plasma concentrations of asparagine, citrulline, ornithine, 1-methylhistidine, and 3-methylhistidine. Significant (P < 0.05) alterations in amino acid concentrations also were identified when cats with CRF were grouped by appetite or severity of renal disease. Amount of dietary protein, body condition, or degree of weight loss had no significant effect on plasma amino acid concentrations. Conclusions - Compared with those in healthy cats, preprandial plasma amino acid profiles in cats with mild, moderate, or severe CRF are abnormal. Clinical Relevance - Despite frequency of altered plasma amino acid concentrations in cats with CRF, the magnitude of these changes is mild and of little clinical relevance. Short-term use of a commercial protein-restricted diet has no deleterious effects on plasma amino acid concentrations. (Am J Vet Res 1999;60:109-113).

AB - Objective - To characterize potential changes in preprandial plasma amino acid concentrations in cats with naturally acquired chronic renal failure (CRF), compared with healthy cats, and to assess potential effects of the severity of renal failure on plasma amino acid concentrations in these cats. Animals - 62 adult cats. Procedure - Preprandial plasma amino acid concentrations were evaluated in 38 cats with mild, moderate, or severe CRF and in 24 apparently healthy cats. Effects of severity of renal failure, amount of dietary protein, degree of weight loss, appetite, and body condition on plasma amino acid profiles were evaluated. Results - Cats with various stages of CRF had significantly (P < 0.05) decreased plasma concentrations of o-hydroxyproline, glutamate, proline, glycine, alanine, tyrosine, tryptophan, and arginine, and significantly increased plasma concentrations of asparagine, citrulline, ornithine, 1-methylhistidine, and 3-methylhistidine. Significant (P < 0.05) alterations in amino acid concentrations also were identified when cats with CRF were grouped by appetite or severity of renal disease. Amount of dietary protein, body condition, or degree of weight loss had no significant effect on plasma amino acid concentrations. Conclusions - Compared with those in healthy cats, preprandial plasma amino acid profiles in cats with mild, moderate, or severe CRF are abnormal. Clinical Relevance - Despite frequency of altered plasma amino acid concentrations in cats with CRF, the magnitude of these changes is mild and of little clinical relevance. Short-term use of a commercial protein-restricted diet has no deleterious effects on plasma amino acid concentrations. (Am J Vet Res 1999;60:109-113).

UR - http://www.scopus.com/inward/record.url?scp=0032615941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032615941&partnerID=8YFLogxK

M3 - Article

VL - 60

SP - 109

EP - 113

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 1

ER -