Abstract
Plasma amino acid concentrations were measured in 36 dogs diagnosed with superficial necrolytic dermatitis (SND) via skin biopsy. The median age of the dogs was 10 years, and 27 out of 36 (75%) were male. Twenty-two out of 36 (61%) of the dogs were accounted for by six breeds; West Highland white terriers (six), Shetland sheepdogs (five), cocker spaniels (four), Scottish terriers (three), Lhasa apsos (two) and Border collies (two). The mean concentration (± standard deviation) was calculated for each measured plasma amino acid and compared to previously documented concentrations of plasma amino acids measured in dogs with acute and chronic hepatitis. The ratio of branched chain amino acids to aromatic amino acids in the dogs with SND was 2.6, slightly lower than that in normal dogs. The mean plasma amino acid concentrations for dogs with SND were significantly lower than for dogs with acute and chronic hepatitis. A metabolic hepatopathy in which there is increased hepatic catabolism of amino acids is hypothesized to explain the hypoaminoacidaemia seen in SND.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 177-186 |
| Number of pages | 10 |
| Journal | Veterinary Dermatology |
| Volume | 13 |
| Issue number | 4 |
| DOIs | |
| State | Published - Aug 2002 |
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Keywords
- Amino acids
- Dog
- Hypoaminoacidaemia
- Metabolic epidermal necrolysis
- SND
- Superficial necrolytic dermatitis
ASJC Scopus subject areas
- veterinary(all)
Cite this
Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis. / Outerbridge, Catherine A; Marks, Stanley L; Rogers, Quinton.
In: Veterinary Dermatology, Vol. 13, No. 4, 08.2002, p. 177-186.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma amino acid concentrations in 36 dogs with histologically confirmed superficial necrolytic dermatitis
AU - Outerbridge, Catherine A
AU - Marks, Stanley L
AU - Rogers, Quinton
PY - 2002/8
Y1 - 2002/8
N2 - Plasma amino acid concentrations were measured in 36 dogs diagnosed with superficial necrolytic dermatitis (SND) via skin biopsy. The median age of the dogs was 10 years, and 27 out of 36 (75%) were male. Twenty-two out of 36 (61%) of the dogs were accounted for by six breeds; West Highland white terriers (six), Shetland sheepdogs (five), cocker spaniels (four), Scottish terriers (three), Lhasa apsos (two) and Border collies (two). The mean concentration (± standard deviation) was calculated for each measured plasma amino acid and compared to previously documented concentrations of plasma amino acids measured in dogs with acute and chronic hepatitis. The ratio of branched chain amino acids to aromatic amino acids in the dogs with SND was 2.6, slightly lower than that in normal dogs. The mean plasma amino acid concentrations for dogs with SND were significantly lower than for dogs with acute and chronic hepatitis. A metabolic hepatopathy in which there is increased hepatic catabolism of amino acids is hypothesized to explain the hypoaminoacidaemia seen in SND.
AB - Plasma amino acid concentrations were measured in 36 dogs diagnosed with superficial necrolytic dermatitis (SND) via skin biopsy. The median age of the dogs was 10 years, and 27 out of 36 (75%) were male. Twenty-two out of 36 (61%) of the dogs were accounted for by six breeds; West Highland white terriers (six), Shetland sheepdogs (five), cocker spaniels (four), Scottish terriers (three), Lhasa apsos (two) and Border collies (two). The mean concentration (± standard deviation) was calculated for each measured plasma amino acid and compared to previously documented concentrations of plasma amino acids measured in dogs with acute and chronic hepatitis. The ratio of branched chain amino acids to aromatic amino acids in the dogs with SND was 2.6, slightly lower than that in normal dogs. The mean plasma amino acid concentrations for dogs with SND were significantly lower than for dogs with acute and chronic hepatitis. A metabolic hepatopathy in which there is increased hepatic catabolism of amino acids is hypothesized to explain the hypoaminoacidaemia seen in SND.
KW - Amino acids
KW - Dog
KW - Hypoaminoacidaemia
KW - Metabolic epidermal necrolysis
KW - SND
KW - Superficial necrolytic dermatitis
UR - http://www.scopus.com/inward/record.url?scp=0036676346&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036676346&partnerID=8YFLogxK
U2 - 10.1046/j.1365-3164.2002.00295.x
DO - 10.1046/j.1365-3164.2002.00295.x
M3 - Article
VL - 13
SP - 177
EP - 186
JO - Veterinary Dermatology
JF - Veterinary Dermatology
SN - 0959-4493
IS - 4
ER -