Plasma 25-hydroxyvitamin D in growing kittens is related to dietary intake of cholecalciferol

James Morris, Kay E. Earle, Phillip A. Andersen

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Vitamin D synthesis by growing kittens exposed to ultraviolet light is ineffective. Concentration of 25-hydroxyvitamin D (25-OHD) in plasma (the most useful index of vitamin D status) was measured in six groups each of seven kittens given a purified diet (12 g calcium and 8 g phosphorus/kg, calculated metabolizable energy = 20 kJ/g) that contained either 0.0, 3.125, 6.25, 12.5, 18.75 or 25 μg of cholecalciferol/kg diet. All kittens received these diets from 9 to 22 wk of age, and the two groups given the 0.0 and 3.125 μg cholecalciferol/kg treatments continued to receive the diets until they were 34 wk old. Total and ionizable calcium and phosphorus in plasma were not affected by treatments. No adverse clinical changes were observed or found on radiographic examination of the kittens at 22 or 34 wk of age. Plasma concentration of 25-OHD was linearly related (r2 = 0.99, P < 0.001) to dietary intake of cholecalciferol. Plasma concentration of 25-OHD in kittens given the diet without added vitamin D was significantly less at 22 wk than at 9 wk, whereas kittens receiving the diet containing 3.125 μg cholecalciferol/kg had significantly higher 25-OHD concentrations at 22 and 34 wk than at 9 wk of age. Kittens given the 6.25 μg cholecalciferol/kg diet had plasma 25-OHD concentrations at 22 wk > 50 nmol/L which is considered replete for humans. An allowance of 6.25 μg (250 IU) of cholecalciferol/kg diet is suggested to provide a margin of safety.

Original languageEnglish (US)
Pages (from-to)909-912
Number of pages4
JournalJournal of Nutrition
Volume129
Issue number4
StatePublished - Apr 16 1999

Fingerprint

kittens
cholecalciferol
Cholecalciferol
food intake
Diet
diet
vitamin D
Vitamin D
Phosphorus
Calcium
calcium
phosphorus
margin of safety
Ultraviolet Rays
metabolizable energy
ultraviolet radiation
Age Groups
25-hydroxyvitamin D
Safety
synthesis

Keywords

  • 25-Hydroxyvitamin D
  • Cats
  • Cholecalciferol
  • Kitten

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Plasma 25-hydroxyvitamin D in growing kittens is related to dietary intake of cholecalciferol. / Morris, James; Earle, Kay E.; Andersen, Phillip A.

In: Journal of Nutrition, Vol. 129, No. 4, 16.04.1999, p. 909-912.

Research output: Contribution to journalArticle

Morris, James ; Earle, Kay E. ; Andersen, Phillip A. / Plasma 25-hydroxyvitamin D in growing kittens is related to dietary intake of cholecalciferol. In: Journal of Nutrition. 1999 ; Vol. 129, No. 4. pp. 909-912.
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