Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals.

Sridevi Devaraj, Ishwarlal Jialal, Sonia Vega-López

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

OBJECTIVE: Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice. METHODS AND RESULTS: After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2%), LDL (12.4%), and non-high-density lipoprotein (HDL) cholesterol (7.8%) compared with baseline and compared with placebo OJ (P<0.01). Apolipoprotein B levels were significantly decreased (9.5%) with sterol OJ. There were no significant changes in HDL cholesterol or triglycerides with the sterol OJ. While folate and B12 levels significantly increased, homocysteine levels were unchanged. CONCLUSIONS: Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen.

Original languageEnglish (US)
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume24
Issue number3
StatePublished - Mar 2004

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Phytosterols
Cholesterol
Sterols
Placebos
LDL Cholesterol
Life Style
Margarine
Diet Therapy
Apolipoproteins B
Homocysteine
Hypercholesterolemia
LDL Lipoproteins
Folic Acid
HDL Cholesterol
Lipoproteins
Coronary Artery Disease
Fasting
Healthy Volunteers
Fats
Therapeutics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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Plant sterol-fortified orange juice effectively lowers cholesterol levels in mildly hypercholesterolemic healthy individuals. / Devaraj, Sridevi; Jialal, Ishwarlal; Vega-López, Sonia.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24, No. 3, 03.2004.

Research output: Contribution to journalArticle

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abstract = "OBJECTIVE: Hypercholesterolemia is a major risk factor for coronary artery disease. Therapeutic lifestyle changes include dietary modifications such as inclusion of phytosterols, which effectively lowers low-density lipoprotein (LDL) cholesterol in margarines and other fats. Their effectiveness in nonfat moieties is not yet established. The aim of this study was to examine if phytosterols alter the plasma lipoprotein profile when incorporated into nonfat orange juice. METHODS AND RESULTS: After a 2-week run-in phase with orange juice, 72 mildly hypercholesterolemic healthy subjects were randomized to receive either placebo orange juice (placebo OJ) or plant sterol-fortified orange juice (sterol OJ) (2g/d) for 8 weeks. Fasting blood was obtained at baseline, after 2 weeks of OJ, and after 8 weeks of placebo/sterol-OJ supplementation. Sterol OJ supplementation significantly decreased total (7.2{\%}), LDL (12.4{\%}), and non-high-density lipoprotein (HDL) cholesterol (7.8{\%}) compared with baseline and compared with placebo OJ (P<0.01). Apolipoprotein B levels were significantly decreased (9.5{\%}) with sterol OJ. There were no significant changes in HDL cholesterol or triglycerides with the sterol OJ. While folate and B12 levels significantly increased, homocysteine levels were unchanged. CONCLUSIONS: Orange juice fortified with plant sterols are effective in reducing LDL cholesterol and could easily be incorporated into the therapeutic lifestyle changes dietary regimen.",
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