Plant NBS-LRR proteins: Adaptable guards

Leah McHale, Xiaoping Tan, Patrice Koehl, Richard W Michelmore

Research output: Contribution to journalArticlepeer-review

608 Scopus citations


The majority of disease resistance genes in plants encode nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies. Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors.

Original languageEnglish (US)
Article number212
JournalGenome Biology
Issue number4
StatePublished - Apr 26 2006

ASJC Scopus subject areas

  • Genetics
  • Cell Biology
  • Ecology, Evolution, Behavior and Systematics


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