Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice

Henriette Van Praag, Melanie J. Lucero, Gene W. Yeo, Kimberly Stecker, Neema Heivand, Chunmei Zhao, Ed Yip, Mia Afanador, Hagen Schroeter, John Hammerstone, Fred H. Gage

Research output: Contribution to journalArticle

187 Citations (Scopus)

Abstract

Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of a plant-derived flavanol, (-)epicatechin, enhances cognition in sedentary or wheel-running female C57BL/6 mice. Retention of spatial memory in the water maze was enhanced by ingestion of (-)epicatechin, especially in combination with exercise. Improved spatial memory was associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus. Moreover, microarray analysis showed upregulation of genes associated with learning and downregulation of markers of neurodegeneration in the hippocampus. Together, our data show that ingestion of a single flavanol improves spatial memory retention in adult mammals.

Original languageEnglish (US)
Pages (from-to)5869-5878
Number of pages10
JournalJournal of Neuroscience
Volume27
Issue number22
DOIs
StatePublished - May 30 2007
Externally publishedYes

Fingerprint

Catechin
Eating
Parahippocampal Gyrus
Neuronal Plasticity
Dentate Gyrus
Microarray Analysis
Inbred C57BL Mouse
Running
Cognition
Mammals
Hippocampus
Cell Survival
Spine
Up-Regulation
Down-Regulation
Learning
Diet
Food
Water
Brain

Keywords

  • (-)Epicatechin
  • Angiogenesis
  • Flavanols
  • Learning and memory
  • Morris water maze
  • Spines

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., ... Gage, F. H. (2007). Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. Journal of Neuroscience, 27(22), 5869-5878. https://doi.org/10.1523/JNEUROSCI.0914-07.2007

Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. / Van Praag, Henriette; Lucero, Melanie J.; Yeo, Gene W.; Stecker, Kimberly; Heivand, Neema; Zhao, Chunmei; Yip, Ed; Afanador, Mia; Schroeter, Hagen; Hammerstone, John; Gage, Fred H.

In: Journal of Neuroscience, Vol. 27, No. 22, 30.05.2007, p. 5869-5878.

Research output: Contribution to journalArticle

Van Praag, H, Lucero, MJ, Yeo, GW, Stecker, K, Heivand, N, Zhao, C, Yip, E, Afanador, M, Schroeter, H, Hammerstone, J & Gage, FH 2007, 'Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice', Journal of Neuroscience, vol. 27, no. 22, pp. 5869-5878. https://doi.org/10.1523/JNEUROSCI.0914-07.2007
Van Praag, Henriette ; Lucero, Melanie J. ; Yeo, Gene W. ; Stecker, Kimberly ; Heivand, Neema ; Zhao, Chunmei ; Yip, Ed ; Afanador, Mia ; Schroeter, Hagen ; Hammerstone, John ; Gage, Fred H. / Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice. In: Journal of Neuroscience. 2007 ; Vol. 27, No. 22. pp. 5869-5878.
@article{3a8e572824a24aa3a92b94fd49cdfcf8,
title = "Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice",
abstract = "Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of a plant-derived flavanol, (-)epicatechin, enhances cognition in sedentary or wheel-running female C57BL/6 mice. Retention of spatial memory in the water maze was enhanced by ingestion of (-)epicatechin, especially in combination with exercise. Improved spatial memory was associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus. Moreover, microarray analysis showed upregulation of genes associated with learning and downregulation of markers of neurodegeneration in the hippocampus. Together, our data show that ingestion of a single flavanol improves spatial memory retention in adult mammals.",
keywords = "(-)Epicatechin, Angiogenesis, Flavanols, Learning and memory, Morris water maze, Spines",
author = "{Van Praag}, Henriette and Lucero, {Melanie J.} and Yeo, {Gene W.} and Kimberly Stecker and Neema Heivand and Chunmei Zhao and Ed Yip and Mia Afanador and Hagen Schroeter and John Hammerstone and Gage, {Fred H.}",
year = "2007",
month = "5",
day = "30",
doi = "10.1523/JNEUROSCI.0914-07.2007",
language = "English (US)",
volume = "27",
pages = "5869--5878",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "22",

}

TY - JOUR

T1 - Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice

AU - Van Praag, Henriette

AU - Lucero, Melanie J.

AU - Yeo, Gene W.

AU - Stecker, Kimberly

AU - Heivand, Neema

AU - Zhao, Chunmei

AU - Yip, Ed

AU - Afanador, Mia

AU - Schroeter, Hagen

AU - Hammerstone, John

AU - Gage, Fred H.

PY - 2007/5/30

Y1 - 2007/5/30

N2 - Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of a plant-derived flavanol, (-)epicatechin, enhances cognition in sedentary or wheel-running female C57BL/6 mice. Retention of spatial memory in the water maze was enhanced by ingestion of (-)epicatechin, especially in combination with exercise. Improved spatial memory was associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus. Moreover, microarray analysis showed upregulation of genes associated with learning and downregulation of markers of neurodegeneration in the hippocampus. Together, our data show that ingestion of a single flavanol improves spatial memory retention in adult mammals.

AB - Diet and exercise have a profound impact on brain function. In particular, natural nutrients found in plants may influence neuronal survival and plasticity. Here, we tested whether consumption of a plant-derived flavanol, (-)epicatechin, enhances cognition in sedentary or wheel-running female C57BL/6 mice. Retention of spatial memory in the water maze was enhanced by ingestion of (-)epicatechin, especially in combination with exercise. Improved spatial memory was associated with increased angiogenesis and neuronal spine density, but not newborn cell survival, in the dentate gyrus of the hippocampus. Moreover, microarray analysis showed upregulation of genes associated with learning and downregulation of markers of neurodegeneration in the hippocampus. Together, our data show that ingestion of a single flavanol improves spatial memory retention in adult mammals.

KW - (-)Epicatechin

KW - Angiogenesis

KW - Flavanols

KW - Learning and memory

KW - Morris water maze

KW - Spines

UR - http://www.scopus.com/inward/record.url?scp=34249805083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249805083&partnerID=8YFLogxK

U2 - 10.1523/JNEUROSCI.0914-07.2007

DO - 10.1523/JNEUROSCI.0914-07.2007

M3 - Article

C2 - 17537957

AN - SCOPUS:34249805083

VL - 27

SP - 5869

EP - 5878

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 22

ER -