Plant-based modulation of toll-like receptors: An emerging therapeutic model

Dev S. Chahal, Raja K Sivamani, Roslyn Rivkah Isseroff, Mohan R. Dasu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Plant-based extracts present a large source of natural immune modulators, many of which have been used in traditional medicine for centuries. Recent research efforts have identified plant extracts as potential modulators of Toll-like receptors (TLRs), the first responders in immunological defenses in normal and disease conditions. This review aims to provide a comprehensive discussion of the modulatory effects of plant-based extracts on TLR expression, signaling, and activation. We organized the review by extraction solvent and plant part showing how they impacted the TLRs. The phytochemical components of the extracts discovered to enable these effects are diverse and vary based on the plant part. The role of the extraction solvent and differences between the different phytochemical components, such as phenolics and polysaccharides, are discussed. Plant extracts hold promising treatments for controlling inflammation and, conversely, for stimulating the immune response. Further research is needed to identify bioactive components of the extracts, mechanisms of their action, and in vivo pharmacological effects using appropriate disease models to ultimately adapt the findings for clinical use.

Original languageEnglish (US)
Pages (from-to)1423-1438
Number of pages16
JournalPhytotherapy Research
Volume27
Issue number10
DOIs
StatePublished - Oct 2013

Fingerprint

Toll-Like Receptors
Plant Extracts
Phytochemicals
Traditional Medicine
Therapeutics
Research
Polysaccharides
Pharmacology
Inflammation

Keywords

  • extract
  • inflammation
  • plant
  • receptor
  • Toll-like

ASJC Scopus subject areas

  • Pharmacology

Cite this

Plant-based modulation of toll-like receptors : An emerging therapeutic model. / Chahal, Dev S.; Sivamani, Raja K; Isseroff, Roslyn Rivkah; Dasu, Mohan R.

In: Phytotherapy Research, Vol. 27, No. 10, 10.2013, p. 1423-1438.

Research output: Contribution to journalArticle

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