Abstract
The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1676-1684 |
| Number of pages | 9 |
| Journal | Chemosphere |
| Volume | 70 |
| Issue number | 9 |
| DOIs | |
| State | Published - Feb 2008 |
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Keywords
- Cord blood
- Hydroxylated PCB metabolites
- Pentachlorophenol
- Polychlorinated biphenyls
- Slovakia
ASJC Scopus subject areas
- Environmental Chemistry
- Environmental Science(all)
Cite this
Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia. / Park, June Soo; Bergman, Åke; Linderholm, Linda; Athanasiadou, Maria; Kocan, Anton; Petrik, Jan; Drobna, Beata; Trnovec, Tomas; Charles, M. Judith; Hertz-Picciotto, Irva.
In: Chemosphere, Vol. 70, No. 9, 02.2008, p. 1676-1684.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia
AU - Park, June Soo
AU - Bergman, Åke
AU - Linderholm, Linda
AU - Athanasiadou, Maria
AU - Kocan, Anton
AU - Petrik, Jan
AU - Drobna, Beata
AU - Trnovec, Tomas
AU - Charles, M. Judith
AU - Hertz-Picciotto, Irva
PY - 2008/2
Y1 - 2008/2
N2 - The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).
AB - The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).
KW - Cord blood
KW - Hydroxylated PCB metabolites
KW - Pentachlorophenol
KW - Polychlorinated biphenyls
KW - Slovakia
UR - http://www.scopus.com/inward/record.url?scp=38349132700&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=38349132700&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2007.07.049
DO - 10.1016/j.chemosphere.2007.07.049
M3 - Article
C2 - 17764717
AN - SCOPUS:38349132700
VL - 70
SP - 1676
EP - 1684
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
IS - 9
ER -