Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia

June Soo Park, Åke Bergman, Linda Linderholm, Maria Athanasiadou, Anton Kocan, Jan Petrik, Beata Drobna, Tomas Trnovec, M. Judith Charles, Irva Hertz-Picciotto

Research output: Contribution to journalArticle

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Abstract

The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).

Original languageEnglish (US)
Pages (from-to)1676-1684
Number of pages9
JournalChemosphere
Volume70
Issue number9
DOIs
StatePublished - Feb 2008

Fingerprint

Pentachlorophenol
Slovakia
Polychlorinated Biphenyls
PCP
Metabolites
Polychlorinated biphenyls
Pregnant Women
PCB
metabolite
serum
Mothers
Serum
Blood
blood
hydroxide ion
woman
Metabolism
Fetal Blood
Placenta
metabolism

Keywords

  • Cord blood
  • Hydroxylated PCB metabolites
  • Pentachlorophenol
  • Polychlorinated biphenyls
  • Slovakia

ASJC Scopus subject areas

  • Environmental Chemistry
  • Environmental Science(all)

Cite this

Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia. / Park, June Soo; Bergman, Åke; Linderholm, Linda; Athanasiadou, Maria; Kocan, Anton; Petrik, Jan; Drobna, Beata; Trnovec, Tomas; Charles, M. Judith; Hertz-Picciotto, Irva.

In: Chemosphere, Vol. 70, No. 9, 02.2008, p. 1676-1684.

Research output: Contribution to journalArticle

Park, JS, Bergman, Å, Linderholm, L, Athanasiadou, M, Kocan, A, Petrik, J, Drobna, B, Trnovec, T, Charles, MJ & Hertz-Picciotto, I 2008, 'Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia', Chemosphere, vol. 70, no. 9, pp. 1676-1684. https://doi.org/10.1016/j.chemosphere.2007.07.049
Park, June Soo ; Bergman, Åke ; Linderholm, Linda ; Athanasiadou, Maria ; Kocan, Anton ; Petrik, Jan ; Drobna, Beata ; Trnovec, Tomas ; Charles, M. Judith ; Hertz-Picciotto, Irva. / Placental transfer of polychlorinated biphenyls, their hydroxylated metabolites and pentachlorophenol in pregnant women from eastern Slovakia. In: Chemosphere. 2008 ; Vol. 70, No. 9. pp. 1676-1684.
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abstract = "The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).",
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AU - Athanasiadou, Maria

AU - Kocan, Anton

AU - Petrik, Jan

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AB - The aim of the present study was to understand the placental transfer of polychlorinated biphenyls (PCBs), specific hydroxylated PCB metabolites (OH-PCBs), and pentachlorophenol (PCP) in blood serum, in a birth cohort from eastern Slovakia. During the period 2002-2004, cord blood specimens were collected in parallel with maternal specimens from women delivering in the two eastern Slovak districts of Michalovce and Svidnik/Stropkov. A total of 92 pairs of mother-cord specimens at delivery were selected for this study. 4-OH-CB107, 3-OH-CB153, 4-OH-CB146, 3′-OH-CB138, 4-OH-CB187, and 4′-OH-CB172 were quantified. The median concentrations of Σ17PCBs, Σ6OH-PCBs, and PCP in cord serum were 0.92, 0.33, and 0.69 ng/g wet wt., respectively and highly correlated with the corresponding maternal serum levels (correlations were R2 = 0.61, 0.78, and 0.82, respectively). The median cord to mother ratios of the Σ17PCBs, Σ6OH-PCBs, and PCP were 0.18, 0.75, and 1.10, respectively. The median ratio of the Σ6OH-PCBs to the Σ17 PCBs in the cord serum was 0.38 from wet weight based concentrations, which was about four times higher than the ratio of these compounds in maternal serum (0.09). PCP was more abundant than any PCB or OH-PCB congener measured in cord serum. The higher cord to maternal ratios of OH-PCB metabolites as compared with the parent compounds suggests either a higher placental transfer rate or greater metabolism in the fetus as compared with the maternal compartment. These findings are consistent with their preferential binding to TTR that can cross the placenta. The cord to maternal ratio varies by congener (e.g., 4-OH-CB107 = 0.58, 4-OH-CB146 = 0.74, 3′-OH-CB138 = 1.01).

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