PKC and PLA2

Probing the complexities of the calcium network

Damian B. van Rossum, Randen L. Patterson

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Lipid signaling and phosphorylation cascades are fundamental to calcium signaling networks. In this review, we will discuss the recent laboratory findings for the phospholipase A2 (PLA2)/protein kinase C (PKC) pathway within cellular calcium networks. The complexity and connectivity of these ubiquitous cellular signals make interpretation of experimental results extremely challenging. We present here computational methods which have been developed to conquer such complex data, and how they can be used to make models capable of accurately predicting cellular responses within multiple calcium signaling pathways. We propose that information obtained from network analysis and computational techniques provides a rich source of knowledge which can be directly translated to the laboratory benchtop.

Original languageEnglish (US)
Pages (from-to)535-545
Number of pages11
JournalCell Calcium
Volume45
Issue number6
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Calcium Signaling
Phospholipases A2
Protein Kinase C
Calcium
Information Services
Phosphorylation
Lipids

Keywords

  • Arachidonic acid
  • Calcium
  • Channel
  • Computational biology
  • Diacylglycerol
  • GDDA-BLAST
  • Lipid
  • Networks
  • Phospholipase A2
  • Phosphorylation
  • Protein kinase C

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

Cite this

PKC and PLA2 : Probing the complexities of the calcium network. / van Rossum, Damian B.; Patterson, Randen L.

In: Cell Calcium, Vol. 45, No. 6, 06.2009, p. 535-545.

Research output: Contribution to journalArticle

van Rossum, Damian B. ; Patterson, Randen L. / PKC and PLA2 : Probing the complexities of the calcium network. In: Cell Calcium. 2009 ; Vol. 45, No. 6. pp. 535-545.
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