Abstract
Resistance to thyroid hormone (RTH) syndrome is an inherited inability to respond appropriately to T3 hormone. In generalized RTH, the T 3 response of both the pituitary and periphery is disrupted. In pituitary (or central) RTH, the ability of the pituitary to sense (and down-regulate) elevated T3 is selectively impaired, whereas the periphery remains relatively T3 responsive, resulting in peripheral thyrotoxicity. Both forms of disease are linked to mutations in thyroid hormone receptor (TR)-β. TRβis expressed by alternate mRNA splicing as two isoforms: TRβ2, found primarily in the pituitary/hypothalamus, and TRβ1, expressed broadly in many tissues. We report here that the wild-type TRβ2 isoform displays an enhanced T3 response relative to the TRβ1 isoform. Mutations associated with generalized RTH (P453S, G345S) impair both TRβ2 and TRβ1 function proportionally, whereas mutations associated with pituitary-specific RTH (R338L, R338W, R429Q) disproportionately disrupt TRβ2 function. We propose that in the normal organism, and in generalized RTH, TRβ2 in the pituitary can sense rising T3 levels in advance of TRβ1 in the periphery, preventing thyrotoxicity. In contrast, the TRβ mutations associated with pituitary RTH disproportionately disrupt the pituitary's ability to sense and suppress elevated T3 levels in advance of the periphery, producing symptoms of thyrotoxicity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1529-1542 |
| Number of pages | 14 |
| Journal | Molecular Endocrinology |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2005 |
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ASJC Scopus subject areas
- Molecular Biology
- Endocrinology, Diabetes and Metabolism
Cite this
Pituitary resistance to thyroid hormone syndrome is associated with T 3 receptor mutants that selectively impair β2 isoform function. / Wan, Wei; Farboud, Behnom; Privalsky, Martin L.
In: Molecular Endocrinology, Vol. 19, No. 6, 06.2005, p. 1529-1542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pituitary resistance to thyroid hormone syndrome is associated with T 3 receptor mutants that selectively impair β2 isoform function
AU - Wan, Wei
AU - Farboud, Behnom
AU - Privalsky, Martin L.
PY - 2005/6
Y1 - 2005/6
N2 - Resistance to thyroid hormone (RTH) syndrome is an inherited inability to respond appropriately to T3 hormone. In generalized RTH, the T 3 response of both the pituitary and periphery is disrupted. In pituitary (or central) RTH, the ability of the pituitary to sense (and down-regulate) elevated T3 is selectively impaired, whereas the periphery remains relatively T3 responsive, resulting in peripheral thyrotoxicity. Both forms of disease are linked to mutations in thyroid hormone receptor (TR)-β. TRβis expressed by alternate mRNA splicing as two isoforms: TRβ2, found primarily in the pituitary/hypothalamus, and TRβ1, expressed broadly in many tissues. We report here that the wild-type TRβ2 isoform displays an enhanced T3 response relative to the TRβ1 isoform. Mutations associated with generalized RTH (P453S, G345S) impair both TRβ2 and TRβ1 function proportionally, whereas mutations associated with pituitary-specific RTH (R338L, R338W, R429Q) disproportionately disrupt TRβ2 function. We propose that in the normal organism, and in generalized RTH, TRβ2 in the pituitary can sense rising T3 levels in advance of TRβ1 in the periphery, preventing thyrotoxicity. In contrast, the TRβ mutations associated with pituitary RTH disproportionately disrupt the pituitary's ability to sense and suppress elevated T3 levels in advance of the periphery, producing symptoms of thyrotoxicity.
AB - Resistance to thyroid hormone (RTH) syndrome is an inherited inability to respond appropriately to T3 hormone. In generalized RTH, the T 3 response of both the pituitary and periphery is disrupted. In pituitary (or central) RTH, the ability of the pituitary to sense (and down-regulate) elevated T3 is selectively impaired, whereas the periphery remains relatively T3 responsive, resulting in peripheral thyrotoxicity. Both forms of disease are linked to mutations in thyroid hormone receptor (TR)-β. TRβis expressed by alternate mRNA splicing as two isoforms: TRβ2, found primarily in the pituitary/hypothalamus, and TRβ1, expressed broadly in many tissues. We report here that the wild-type TRβ2 isoform displays an enhanced T3 response relative to the TRβ1 isoform. Mutations associated with generalized RTH (P453S, G345S) impair both TRβ2 and TRβ1 function proportionally, whereas mutations associated with pituitary-specific RTH (R338L, R338W, R429Q) disproportionately disrupt TRβ2 function. We propose that in the normal organism, and in generalized RTH, TRβ2 in the pituitary can sense rising T3 levels in advance of TRβ1 in the periphery, preventing thyrotoxicity. In contrast, the TRβ mutations associated with pituitary RTH disproportionately disrupt the pituitary's ability to sense and suppress elevated T3 levels in advance of the periphery, producing symptoms of thyrotoxicity.
UR - http://www.scopus.com/inward/record.url?scp=22344443370&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22344443370&partnerID=8YFLogxK
U2 - 10.1210/me.2005-0014
DO - 10.1210/me.2005-0014
M3 - Article
C2 - 15802373
AN - SCOPUS:22344443370
VL - 19
SP - 1529
EP - 1542
JO - Molecular Endocrinology
JF - Molecular Endocrinology
SN - 0888-8809
IS - 6
ER -