Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Corey Raffel; James E Boggan; Lawrence F. Eng; Richard L. Davis; Charles B. Wilson

doi:10.1016/0090-3019(88)90097-3

Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Corey Raffel, James E Boggan, Lawrence F. Eng, Richard L. Davis, Charles B. Wilson

Neurological Surgery

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.

Original language	English (US)
Pages (from-to)	125-130
Number of pages	6
Journal	Surgical Neurology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/0090-3019(88)90097-3
State	Published - 1988

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Keywords

Cushing's disease
Intermediate lobe
Monoclonal antibody

ASJC Scopus subject areas

Clinical Neurology
Surgery

Cite this

Raffel, C., Boggan, J. E., Eng, L. F., Davis, R. L., & Wilson, C. B. (1988). Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe? Surgical Neurology, 30(2), 125-130. https://doi.org/10.1016/0090-3019(88)90097-3

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10.1016/0090-3019(88)90097-3