Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Corey Raffel; James E Boggan; Lawrence F. Eng; Richard L. Davis; Charles B. Wilson

doi:10.1016/0090-3019(88)90097-3

Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Corey Raffel, James E Boggan, Lawrence F. Eng, Richard L. Davis, Charles B. Wilson

Neurological Surgery

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10 Scopus citations

Abstract

Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.

Original language	English (US)
Pages (from-to)	125-130
Number of pages	6
Journal	Surgical Neurology
Volume	30
Issue number	2
DOIs	https://doi.org/10.1016/0090-3019(88)90097-3
State	Published - 1988

Keywords

Cushing's disease
Intermediate lobe
Monoclonal antibody

ASJC Scopus subject areas

Clinical Neurology
Surgery

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10.1016/0090-3019(88)90097-3

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title = "Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?",

abstract = "Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.",

keywords = "Cushing's disease, Intermediate lobe, Monoclonal antibody",

author = "Corey Raffel and Boggan, {James E} and Eng, {Lawrence F.} and Davis, {Richard L.} and Wilson, {Charles B.}",

year = "1988",

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AU - Raffel, Corey

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AU - Eng, Lawrence F.

AU - Davis, Richard L.

AU - Wilson, Charles B.

PY - 1988

Y1 - 1988

N2 - Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.

AB - Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.

KW - Cushing's disease

KW - Intermediate lobe

KW - Monoclonal antibody

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ER -

Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Abstract

Keywords

ASJC Scopus subject areas

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