Abstract
Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-130 |
| Number of pages | 6 |
| Journal | Surgical Neurology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
Keywords
- Cushing's disease
- Intermediate lobe
- Monoclonal antibody
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
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Raffel, C., Boggan, J. E., Eng, L. F., Davis, R. L., & Wilson, C. B. (1988). Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe? Surgical Neurology, 30(2), 125-130. https://doi.org/10.1016/0090-3019(88)90097-3