Abstract
Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-130 |
| Number of pages | 6 |
| Journal | Surgical Neurology |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1988 |
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Keywords
- Cushing's disease
- Intermediate lobe
- Monoclonal antibody
ASJC Scopus subject areas
- Clinical Neurology
- Surgery
Cite this
Pituitary adenomas in cushing's disease : Do they arise from the intermediate lobe? / Raffel, Corey; Boggan, James E; Eng, Lawrence F.; Davis, Richard L.; Wilson, Charles B.
In: Surgical Neurology, Vol. 30, No. 2, 1988, p. 125-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pituitary adenomas in cushing's disease
T2 - Do they arise from the intermediate lobe?
AU - Raffel, Corey
AU - Boggan, James E
AU - Eng, Lawrence F.
AU - Davis, Richard L.
AU - Wilson, Charles B.
PY - 1988
Y1 - 1988
N2 - Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
AB - Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.
KW - Cushing's disease
KW - Intermediate lobe
KW - Monoclonal antibody
UR - http://www.scopus.com/inward/record.url?scp=0023801831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023801831&partnerID=8YFLogxK
U2 - 10.1016/0090-3019(88)90097-3
DO - 10.1016/0090-3019(88)90097-3
M3 - Article
C2 - 2456624
AN - SCOPUS:0023801831
VL - 30
SP - 125
EP - 130
JO - World Neurosurgery
JF - World Neurosurgery
SN - 1878-8750
IS - 2
ER -