Pituitary adenomas in cushing's disease: Do they arise from the intermediate lobe?

Corey Raffel, James E Boggan, Lawrence F. Eng, Richard L. Davis, Charles B. Wilson

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Pituitary adenomas from 15 patients with Cushing's disease were studied histopathologically. The tumors were examined for the presence of neural axons by the Bodian silver impregnation technique and a specific immunohistologic technique based on a monoclonal antibody to axonal neurofilaments. Axons were not seen in any of the surgical specimens. This finding suggests that most, if not all, adrenocorticotropin-secreting pituitary adenomas are of anterior lobe origin.

Original languageEnglish (US)
Pages (from-to)125-130
Number of pages6
JournalSurgical Neurology
Volume30
Issue number2
DOIs
StatePublished - 1988

Keywords

  • Cushing's disease
  • Intermediate lobe
  • Monoclonal antibody

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery

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