Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

Yong Sam Jung; Yingjuan Qian; Xinbin Chen

doi:10.1016/j.febslet.2012.03.052

Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

Yong Sam Jung, Yingjuan Qian, Xinbin Chen

Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C ₃H ₂C ₃ type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.

Original language	English (US)
Pages (from-to)	1397-1402
Number of pages	6
Journal	FEBS Letters
Volume	586
Issue number	10
DOIs	https://doi.org/10.1016/j.febslet.2012.03.052
State	Published - May 21 2012

Keywords

Cancer therapy
E3 ligase
Pirh2
Tumorigenesis

ASJC Scopus subject areas

Biochemistry
Biophysics
Cell Biology
Genetics
Molecular Biology
Structural Biology

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Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

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