Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

Yong Sam Jung, Yingjuan Qian, Xinbin Chen

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C 3H 2C 3 type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.

Original languageEnglish (US)
Pages (from-to)1397-1402
Number of pages6
JournalFEBS Letters
Volume586
Issue number10
DOIs
StatePublished - May 21 2012

Keywords

  • Cancer therapy
  • E3 ligase
  • Pirh2
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

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