Abstract
The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C 3H 2C 3 type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1397-1402 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 586 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 21 2012 |
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Keywords
- Cancer therapy
- E3 ligase
- Pirh2
- Tumorigenesis
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Structural Biology
Cite this
Pirh2 RING-finger E3 ubiquitin ligase : Its role in tumorigenesis and cancer therapy. / Jung, Yong Sam; Qian, Yingjuan; Chen, Xinbin.
In: FEBS Letters, Vol. 586, No. 10, 21.05.2012, p. 1397-1402.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pirh2 RING-finger E3 ubiquitin ligase
T2 - Its role in tumorigenesis and cancer therapy
AU - Jung, Yong Sam
AU - Qian, Yingjuan
AU - Chen, Xinbin
PY - 2012/5/21
Y1 - 2012/5/21
N2 - The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C 3H 2C 3 type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.
AB - The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C 3H 2C 3 type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.
KW - Cancer therapy
KW - E3 ligase
KW - Pirh2
KW - Tumorigenesis
UR - http://www.scopus.com/inward/record.url?scp=84861194412&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861194412&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2012.03.052
DO - 10.1016/j.febslet.2012.03.052
M3 - Article
C2 - 22673504
AN - SCOPUS:84861194412
VL - 586
SP - 1397
EP - 1402
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 10
ER -