Pirh2 RING-finger E3 ubiquitin ligase: Its role in tumorigenesis and cancer therapy

Yong Sam Jung, Yingjuan Qian, Xinbin Chen

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The ubiquitin-dependent proteasome system plays a critical role in many cellular processes and pathogenesis of various human diseases, including cancer. Although there are a large number of E3 ubiquitin ligases, the majority are RING-finger type E3s. Pirh2, a target of p53 transcription factor, contains a highly conserved C 3H 2C 3 type RING domain. Importantly, Pirh2 was found to regulate a group of key factors dedicated to the DNA damage response, such as p53, p73, PolH, and c-Myc. Interestingly, Pirh2 was upregulated or downregulated in different types of cancers. These suggest that Pirh2 is implicated in either promoting or suppressing tumor progression in a tissue-dependent manner. This review will focus on the major findings in these studies and discuss the potential to explore Pirh2 as a cancer therapeutic target.

Original languageEnglish (US)
Pages (from-to)1397-1402
Number of pages6
JournalFEBS Letters
Volume586
Issue number10
DOIs
StatePublished - May 21 2012

Fingerprint

Ubiquitin-Protein Ligases
Proteasome Endopeptidase Complex
Ubiquitin
Fingers
Tumors
Carcinogenesis
Transcription Factors
Tissue
DNA
Neoplasms
Therapeutics
DNA Damage
Down-Regulation

Keywords

  • Cancer therapy
  • E3 ligase
  • Pirh2
  • Tumorigenesis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Pirh2 RING-finger E3 ubiquitin ligase : Its role in tumorigenesis and cancer therapy. / Jung, Yong Sam; Qian, Yingjuan; Chen, Xinbin.

In: FEBS Letters, Vol. 586, No. 10, 21.05.2012, p. 1397-1402.

Research output: Contribution to journalArticle

Jung, Yong Sam ; Qian, Yingjuan ; Chen, Xinbin. / Pirh2 RING-finger E3 ubiquitin ligase : Its role in tumorigenesis and cancer therapy. In: FEBS Letters. 2012 ; Vol. 586, No. 10. pp. 1397-1402.
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