Pioneer neurones use basal lamina as a substratum for outgrowth in the embryonic grasshopper limb

H. Anderson, Richard P Tucker

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

During axonogenesis, contacts made by the growth cone with its substratum are important in guiding the direction of neurone outgrowth. This study examines the contacts made by the growth cones of pioneer neurones in the embryonic grasshopper limb. Individual pioneer neurones at different stages of development were injected with horseradish peroxidase and the contacts made by the filopodia at the tip of their growth cones were examined by electron microscopy. Filopodia made few contacts with mesodermal cells, some contacts with ectodermal cells and very frequent contacts with basal lamina underlying the ectoderm. Components of the basal lamina may therefore play a role in guiding pioneer axon outgrowth.

Original languageEnglish (US)
Pages (from-to)601-608
Number of pages8
JournalDevelopment
Volume104
Issue number4
StatePublished - 1988

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

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