Pin1: a molecular orchestrator in the heart

Nirmala Hariharan, Mark A. Sussman

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Pin1 is an evolutionarily conserved peptidyl-prolyl isomerase that binds and changes the three-dimensional conformation of specific phospho-proteins. By regulating protein structure and folding, Pin1 affects the stability, interaction, and activity of a broad spectrum of target proteins, thus impacting upon diverse cellular processes. This review discusses the pivotal role Pin1 plays in regulating cardiac pathophysiology by functioning as a "molecular orchestrator" of a myriad of signal transduction pathways in the heart.

Original languageEnglish (US)
Pages (from-to)256-262
Number of pages7
JournalTrends in Cardiovascular Medicine
Volume24
Issue number6
DOIs
StatePublished - Aug 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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