Pilot immunization of mice infected with an equine strain of Corynebacterium pseudotuberculosis.

Jennifer K. Gorman, Mourad Gabriel, N. James MacLachlan, Nathan Nieto, Janet Foley, Sharon Spier

Research output: Contribution to journalArticle

Abstract

This pilot study evaluated protection of an equine autogenous bacterin-toxoid vaccine against Corynebacterium pseudotuberculosis infection. Twenty-four BALB/c mice were inoculated with two doses of bacterin-toxoid vaccine or two injections of a placebo. Clinical, microbiologic, and pathologic outcomes were assessed after intradermal infection with one of two equine-origin C. pseudotuberculosis strains. Mice receiving bacterin-toxoid from fast-growing C. pseudotuberculosis showed significant protection from challenge infection, as evidenced by a higher survival rate, fewer gross and histopathologic lesions, and lower bacterial levels on culture. Successful protection via a vaccine against equine internal abscesses might provide supplementary management options against an important, potentially fatal disease.

Original languageEnglish (US)
JournalVeterinary therapeutics : research in applied veterinary medicine
Volume11
Issue number1
StatePublished - Mar 2010
Externally publishedYes

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Corynebacterium pseudotuberculosis
Bacterial Vaccines
Toxoids
toxoids
Horses
Immunization
immunization
Vaccines
vaccines
horses
mice
Corynebacterium Infections
infection
abscess
Infection
Abscess
placebos
survival rate
Placebos
injection

ASJC Scopus subject areas

  • veterinary(all)

Cite this

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AU - Gabriel, Mourad

AU - MacLachlan, N. James

AU - Nieto, Nathan

AU - Foley, Janet

AU - Spier, Sharon

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