Abstract
Objective: Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only been reported for reducing prevalent VMS, not preventing newly developing VMS. We analyzed longitudinal data from the Study of Women's Health Across the Nation for the relation of dietary phytoestrogen and fiber intake to incident VMS in this multiracial/ethnic cohort. METHODS: The Study of Women's Health Across the Nation included 3,302 premenopausal and early perimenopausal women, 1,651 of whom reported no VMS at baseline and were followed with annual visits for 10 years. Dietary intakes of isoflavones, coumestrol, lignans, and fiber were assessed by a food frequency questionnaire at baseline and in annual visits 5 and 9 and interpolated for intervening years. The number of days experiencing VMS in the past 2 weeks was self-reported annually. Using multinomial logistic regression with generalized estimating equations, we modeled incident VMS in relation to isoflavones, lignans, fiber, coumestrol, or total phytoestrogen intake and covariates. RESULTS: No consistent monotonic relations were observed between any dietary phytoestrogen or fiber and incident VMS, although adjusted odds ratios for some individual quartiles were statistically significant. CONCLUSIONS: For certainty of any effect of dietary phytoestrogens or fiber on the prevention of incident VMS, a randomized, placebo-controlled, double-masked trial with sufficient numbers of women in different racial/ethnic, menopausal status, and metabolic groups over years of follow-up is required, but our results suggest that a clinically significant or large effect is improbable.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 308-314 |
| Number of pages | 7 |
| Journal | Menopause |
| Volume | 20 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2013 |
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Keywords
- Diet
- Menopause
- Phytoestrogens
- Race/ethnicity
- Vasomotor symptoms
ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Phytoestrogen and fiber intakes in relation to incident vasomotor symptoms : Results from the Study of Women's Health Across the Nation. / Gold, Ellen B; Leung, Katherine; Crawford, Sybil L.; Huang, Mei Hua; Waetjen, L Elaine; Greendale, Gail A.
In: Menopause, Vol. 20, No. 3, 03.2013, p. 308-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phytoestrogen and fiber intakes in relation to incident vasomotor symptoms
T2 - Results from the Study of Women's Health Across the Nation
AU - Gold, Ellen B
AU - Leung, Katherine
AU - Crawford, Sybil L.
AU - Huang, Mei Hua
AU - Waetjen, L Elaine
AU - Greendale, Gail A.
PY - 2013/3
Y1 - 2013/3
N2 - Objective: Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only been reported for reducing prevalent VMS, not preventing newly developing VMS. We analyzed longitudinal data from the Study of Women's Health Across the Nation for the relation of dietary phytoestrogen and fiber intake to incident VMS in this multiracial/ethnic cohort. METHODS: The Study of Women's Health Across the Nation included 3,302 premenopausal and early perimenopausal women, 1,651 of whom reported no VMS at baseline and were followed with annual visits for 10 years. Dietary intakes of isoflavones, coumestrol, lignans, and fiber were assessed by a food frequency questionnaire at baseline and in annual visits 5 and 9 and interpolated for intervening years. The number of days experiencing VMS in the past 2 weeks was self-reported annually. Using multinomial logistic regression with generalized estimating equations, we modeled incident VMS in relation to isoflavones, lignans, fiber, coumestrol, or total phytoestrogen intake and covariates. RESULTS: No consistent monotonic relations were observed between any dietary phytoestrogen or fiber and incident VMS, although adjusted odds ratios for some individual quartiles were statistically significant. CONCLUSIONS: For certainty of any effect of dietary phytoestrogens or fiber on the prevention of incident VMS, a randomized, placebo-controlled, double-masked trial with sufficient numbers of women in different racial/ethnic, menopausal status, and metabolic groups over years of follow-up is required, but our results suggest that a clinically significant or large effect is improbable.
AB - Objective: Although reduction of vasomotor symptoms (VMS; hot flashes and night sweats) has been reported in postmenopausal women who used isoflavones, a clear dose response has not been shown, has largely not been reported for perimenopausal women, and has largely only been reported for reducing prevalent VMS, not preventing newly developing VMS. We analyzed longitudinal data from the Study of Women's Health Across the Nation for the relation of dietary phytoestrogen and fiber intake to incident VMS in this multiracial/ethnic cohort. METHODS: The Study of Women's Health Across the Nation included 3,302 premenopausal and early perimenopausal women, 1,651 of whom reported no VMS at baseline and were followed with annual visits for 10 years. Dietary intakes of isoflavones, coumestrol, lignans, and fiber were assessed by a food frequency questionnaire at baseline and in annual visits 5 and 9 and interpolated for intervening years. The number of days experiencing VMS in the past 2 weeks was self-reported annually. Using multinomial logistic regression with generalized estimating equations, we modeled incident VMS in relation to isoflavones, lignans, fiber, coumestrol, or total phytoestrogen intake and covariates. RESULTS: No consistent monotonic relations were observed between any dietary phytoestrogen or fiber and incident VMS, although adjusted odds ratios for some individual quartiles were statistically significant. CONCLUSIONS: For certainty of any effect of dietary phytoestrogens or fiber on the prevention of incident VMS, a randomized, placebo-controlled, double-masked trial with sufficient numbers of women in different racial/ethnic, menopausal status, and metabolic groups over years of follow-up is required, but our results suggest that a clinically significant or large effect is improbable.
KW - Diet
KW - Menopause
KW - Phytoestrogens
KW - Race/ethnicity
KW - Vasomotor symptoms
UR - http://www.scopus.com/inward/record.url?scp=84874763354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84874763354&partnerID=8YFLogxK
U2 - 10.1097/GME.0b013e31826d2f43
DO - 10.1097/GME.0b013e31826d2f43
M3 - Article
C2 - 23435028
AN - SCOPUS:84874763354
VL - 20
SP - 308
EP - 314
JO - Menopause
JF - Menopause
SN - 1072-3714
IS - 3
ER -