Abstract
The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1 and mTORC2 as well as their upstream modulators, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), and their downstream targets in various dermatologic diseases. Phytochemicals, plant-derived naturally occurring compounds, have been shown to regulate the mTOR pathway and may serve as novel therapeutic agents in dermatological disease. Here, we review phytochemicals in the context of the mTOR pathway and their potential use in cutaneous disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 861-871 |
| Number of pages | 11 |
| Journal | Archives of Dermatological Research |
| Volume | 306 |
| Issue number | 10 |
| DOIs | |
| State | Published - Dec 1 2014 |
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ASJC Scopus subject areas
- Medicine(all)
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Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease. / Leo, Michael S.; Sivamani, Raja K.
In: Archives of Dermatological Research, Vol. 306, No. 10, 01.12.2014, p. 861-871.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Phytochemical modulation of the Akt/mTOR pathway and its potential use in cutaneous disease
AU - Leo, Michael S.
AU - Sivamani, Raja K
PY - 2014/12/1
Y1 - 2014/12/1
N2 - The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1 and mTORC2 as well as their upstream modulators, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), and their downstream targets in various dermatologic diseases. Phytochemicals, plant-derived naturally occurring compounds, have been shown to regulate the mTOR pathway and may serve as novel therapeutic agents in dermatological disease. Here, we review phytochemicals in the context of the mTOR pathway and their potential use in cutaneous disease.
AB - The mechanistic target of rapamycin (mTOR) is involved in the regulation of cellular growth, proliferation, lipid synthesis, and protein translation. The mTOR pathway involves two complexes: the mechanistic target of rapamycin complex 1 (mTORC1) and the mechanistic target of rapamycin complex 2 (mTORC2). Both mTOR complexes have been implicated in the development and progression of various skin diseases including melanoma, psoriasis, and acne vulgaris. Here, we review the role of both mTORC1 and mTORC2 as well as their upstream modulators, phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt), and their downstream targets in various dermatologic diseases. Phytochemicals, plant-derived naturally occurring compounds, have been shown to regulate the mTOR pathway and may serve as novel therapeutic agents in dermatological disease. Here, we review phytochemicals in the context of the mTOR pathway and their potential use in cutaneous disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=84936134638&partnerID=8YFLogxK
U2 - 10.1007/s00403-014-1480-8
DO - 10.1007/s00403-014-1480-8
M3 - Article
C2 - 24972910
AN - SCOPUS:84936134638
VL - 306
SP - 861
EP - 871
JO - Archives of Dermatological Research
JF - Archives of Dermatological Research
SN - 0340-3696
IS - 10
ER -