Phytic acid-trace element (Zn, Cu, Mn) interactions

Bo Lönnerdal

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Studies in animals and human subjects have shown that diets high in phytic acid can cause zinc deficiency, and that the phytate content is negatively correlated to zinc absorption. Suboptimal zinc status has been shown to cause increased morbidity, poor pregnancy outcome, impaired growth, immune competence and cognitive function, emphasizing the need to optimize zinc bioavailability. Reducing the content of phytate in the diet is one way of improving zinc absorption and this can be achieved by novel precipitation methods during processing, food preparation methods that activate endogenous phytase (e.g. baking, fermentation, malting and hydrothermal processing), or addition of exogenous phytase. During the action of phytase on phytic acid, the hexaphosphate is hydrolysed into inositol phosphates with lower degrees of phosphorylation. Because only the penta- and hexaphosphates have been shown to inhibit zinc absorption, it is often essential to analyze the individual forms of phytate in the diet when evaluating zinc bioavailability. Phytic acid does not inhibit copper absorption, but has a modest inhibitory effect on manganese absorption.

Original languageEnglish (US)
Pages (from-to)749-758
Number of pages10
JournalInternational Journal of Food Science and Technology
Volume37
Issue number7
DOIs
StatePublished - Oct 2002

Fingerprint

Phytic Acid
Trace Elements
Trace elements
phytic acid
trace elements
Zinc
zinc
6-Phytase
Acids
phytases
Nutrition
Diet
Biological Availability
bioavailability
diet
inositol phosphates
Pentas
Food processing
pregnancy outcome
Rubiaceae

Keywords

  • Copper
  • Manganese
  • Phytase
  • Phytate
  • Phytic acid
  • Zinc

ASJC Scopus subject areas

  • Food Science

Cite this

Phytic acid-trace element (Zn, Cu, Mn) interactions. / Lönnerdal, Bo.

In: International Journal of Food Science and Technology, Vol. 37, No. 7, 10.2002, p. 749-758.

Research output: Contribution to journalArticle

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