Physiology of cholangiocytes

James H. Tabibian, Anatoliy I. Masyuk, Tetyana V. Masyuk, Steven P. O'Hara, Nicholas F. LaRusso

Research output: Contribution to journalArticle

82 Scopus citations


Cholangiocytes are epithelial cells that line the intra- and extrahepatic ducts of the biliary tree. The main physiologic function of cholangiocytes ismodification of hepatocyte-derived bile, an intricate process regulated by hormones, peptides, nucleotides, neurotransmitters, and other molecules through intracellular signaling pathways and cascades. The mechanisms and regulation of bile modification are reviewed herein.

Original languageEnglish (US)
Pages (from-to)541-565
Number of pages25
JournalComprehensive Physiology
Issue number1
StatePublished - 2013
Externally publishedYes


ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013). Physiology of cholangiocytes. Comprehensive Physiology, 3(1), 541-565.