Physiological and morphological identification of a nonpyramidal hippocampal cell type

Philip A Schwartzkroin, Lawrence H. Mathers

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Abstract

In intracellular recordings from the CAI region of the hippocampal slice preparation, an infrequent cell type different from the predominant pyramidal cell has been characterized. The cells have very brief spikes, large hyperpolarizing after-potentials, and tend to fire at a high spontaneous rate; unitary synaptic potentials are visible in the baseline. Stimulation in stratum radiatum evokes an EPSP which often triggers a short burst of spikes; an IPSP invariably follows the initial excitation. Intracellular injection of HRP into these cells shows them to be a non-pyramidal cell type with extensive local axon ramification; however, they do not resemble the classical basket cell. These cells are, nevertheless, candidates for an interneuron in hippocampus.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalBrain Research
Volume157
Issue number1
DOIs
StatePublished - Nov 17 1978
Externally publishedYes

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ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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