Physical properties and biocompatibility of a porous chitosan-based fiber-reinforced conduit for nerve regeneration

Aijun Wang, Qiang Ao, Yujun Wei, Kai Gong, Xuesong Liu, Nanming Zhao, Yandao Gong, Xiufang Zhang

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

Porous fiber-reinforced chitosan nerve conduits were fabricated from chitosan yarns and a chitosan solution by combining an industrial braiding method with a mold casting/lyophilization technique. The conduits were permeable to molecules ranging in molecular size from 180 Da (glucose) to 66,200 Da (BSA). The compressive load of the reinforced conduits was significantly higher than that of a non-reinforced control conduit at equal levels of strain. The tensile strength of the reinforced conduits was also increased from 0.41 ± 0.17 to 3.69 ± 0.64 MPa. An in vitro cytotoxicity test showed the conduits were not cytotoxic to Neuro-2a cells. Preliminary in vivo implantation testing indicated that the conduits were compatible with the surrounding tissue.

Original languageEnglish (US)
Pages (from-to)1697-1702
Number of pages6
JournalBiotechnology Letters
Volume29
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

Keywords

  • Chitosan
  • Fiber
  • Nerve conduit
  • Nerve regeneration

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Microbiology
  • Bioengineering

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