Physical mapping of the retinoid X receptor B gene in mouse and human

Toshi Nagata, Elizabeth H. Weiss, Kuniya Abe, Kyoko Kitagawa, Asako Ando, Yukie Yara-Kikuti, Michael F Seldin, Keiko Ozato, Hidetoshi Inoko, Makoto Taketo

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Retinoid X receptors (RXRs) are zinc finger-containing nuclear transcription factors. They belong to the nuclear receptor superfamily that contains retinoid receptors, vitamin D receptors, thyroid hormone receptors, and steroid hormone receptors as well as the so-called orphan receptors. We previously mapped all three RXR genes on mouse chromosomes, using a panel of Mus spretus-Mus musculus interspecific backcross mice: Namely, the RXRA- gene (Rxra) on Chr 2 near the centromere, the RXRB gene (Rxrb) on Chr 17 in the H2 region, and the RXRG gene (Rxrg) on distal Chr 1. Using cosmid clones that cover the major histocompatibility complex (MHC) region, we determined the precise physical map positions of the gene encoding mouse and human RXRB, respectively. The mouse gene (Rxrb) maps between H2-Ke4 and H2-Ke5: namely, immediately telomeric to H2-Ke4 which encodes a histidine-rich transmembrane protein, and 12 kilobases centromeric to H2-Ke5 which is expressed in lymphoid tissues. Rxrb and H2-Ke4 are transcribed into opposite directions from a CpG-rich promoter of about 250 base pairs. This gene organization is well conserved also in the human genome at the HLA-DP subregion of CHr 6p, underscoring the strong conservation of the gene organization in the MHC region between the two mammals.

Original languageEnglish (US)
Pages (from-to)83-90
Number of pages8
JournalImmunogenetics
Volume41
Issue number2-3
DOIs
StatePublished - Jan 1995
Externally publishedYes

Fingerprint

Retinoid X Receptors
Genes
Major Histocompatibility Complex
HLA-DP Antigens
Thyroid Hormone Receptors
Cosmids
Calcitriol Receptors
Gene Order
Centromere
Steroid Receptors
Zinc Fingers
Retinoids
Lymphoid Tissue
Human Genome
Cytoplasmic and Nuclear Receptors
Base Pairing
Mammals
Transcription Factors
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Nagata, T., Weiss, E. H., Abe, K., Kitagawa, K., Ando, A., Yara-Kikuti, Y., ... Taketo, M. (1995). Physical mapping of the retinoid X receptor B gene in mouse and human. Immunogenetics, 41(2-3), 83-90. https://doi.org/10.1007/BF00182317

Physical mapping of the retinoid X receptor B gene in mouse and human. / Nagata, Toshi; Weiss, Elizabeth H.; Abe, Kuniya; Kitagawa, Kyoko; Ando, Asako; Yara-Kikuti, Yukie; Seldin, Michael F; Ozato, Keiko; Inoko, Hidetoshi; Taketo, Makoto.

In: Immunogenetics, Vol. 41, No. 2-3, 01.1995, p. 83-90.

Research output: Contribution to journalArticle

Nagata, T, Weiss, EH, Abe, K, Kitagawa, K, Ando, A, Yara-Kikuti, Y, Seldin, MF, Ozato, K, Inoko, H & Taketo, M 1995, 'Physical mapping of the retinoid X receptor B gene in mouse and human', Immunogenetics, vol. 41, no. 2-3, pp. 83-90. https://doi.org/10.1007/BF00182317
Nagata T, Weiss EH, Abe K, Kitagawa K, Ando A, Yara-Kikuti Y et al. Physical mapping of the retinoid X receptor B gene in mouse and human. Immunogenetics. 1995 Jan;41(2-3):83-90. https://doi.org/10.1007/BF00182317
Nagata, Toshi ; Weiss, Elizabeth H. ; Abe, Kuniya ; Kitagawa, Kyoko ; Ando, Asako ; Yara-Kikuti, Yukie ; Seldin, Michael F ; Ozato, Keiko ; Inoko, Hidetoshi ; Taketo, Makoto. / Physical mapping of the retinoid X receptor B gene in mouse and human. In: Immunogenetics. 1995 ; Vol. 41, No. 2-3. pp. 83-90.
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