Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1

Stephen F. Kingsmore, Jay Snoddy, Divaker Choubey, Peter Lengyel, Michael F Seldin

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

This report defines genetic and physical relationships among α-spectrin (Spna-1), serum amyloid P-component (Sap), and a family of interferon-activated genes, provisionally designated Ifi202, Ifi203, and Ifi204. By linkage analysis using a large panel of interspecific backcross mice, Sap, Ifi202, and Ifi204 were shown to be tightly linked to Spna-1 on distal mouse chromosome 1. By pulsed field electrophoresis, a genomic restriction map of 6400 kb of distal mouse chromosome 1 was generated, linking genes encoding Sap, (Ifi202, Ifi203, Ifi204), and Spna-1 in that order within 450-1000 kb (where the genes within brackets were not ordered). The interferon-activated genes Ifi202, Ifi203, and Ifi204 were linked within 75-150 kb. Furthermore, genes transcriptionally activated by cytokines, namely Sap, Ifi202, Ifi203, and Ifi204, were located within 450 kb. These studies suggest the possibility that selective pressure may maintain in physical proximity gene clusters which are under coordinate transcriptional control.

Original languageEnglish (US)
Pages (from-to)169-174
Number of pages6
JournalImmunogenetics
Volume30
Issue number3
DOIs
StatePublished - Sep 1989
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Genetics

Fingerprint Dive into the research topics of 'Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1'. Together they form a unique fingerprint.

  • Cite this