Abstract
This report defines genetic and physical relationships among α-spectrin (Spna-1), serum amyloid P-component (Sap), and a family of interferon-activated genes, provisionally designated Ifi202, Ifi203, and Ifi204. By linkage analysis using a large panel of interspecific backcross mice, Sap, Ifi202, and Ifi204 were shown to be tightly linked to Spna-1 on distal mouse chromosome 1. By pulsed field electrophoresis, a genomic restriction map of 6400 kb of distal mouse chromosome 1 was generated, linking genes encoding Sap, (Ifi202, Ifi203, Ifi204), and Spna-1 in that order within 450-1000 kb (where the genes within brackets were not ordered). The interferon-activated genes Ifi202, Ifi203, and Ifi204 were linked within 75-150 kb. Furthermore, genes transcriptionally activated by cytokines, namely Sap, Ifi202, Ifi203, and Ifi204, were located within 450 kb. These studies suggest the possibility that selective pressure may maintain in physical proximity gene clusters which are under coordinate transcriptional control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-174 |
| Number of pages | 6 |
| Journal | Immunogenetics |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| State | Published - Sep 1989 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Genetics
Cite this
Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1. / Kingsmore, Stephen F.; Snoddy, Jay; Choubey, Divaker; Lengyel, Peter; Seldin, Michael F.
In: Immunogenetics, Vol. 30, No. 3, 09.1989, p. 169-174.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Physical mapping of a family of interferon-activated genes, serum amyloid P-component, and α-spectrin on mouse chromosome 1
AU - Kingsmore, Stephen F.
AU - Snoddy, Jay
AU - Choubey, Divaker
AU - Lengyel, Peter
AU - Seldin, Michael F
PY - 1989/9
Y1 - 1989/9
N2 - This report defines genetic and physical relationships among α-spectrin (Spna-1), serum amyloid P-component (Sap), and a family of interferon-activated genes, provisionally designated Ifi202, Ifi203, and Ifi204. By linkage analysis using a large panel of interspecific backcross mice, Sap, Ifi202, and Ifi204 were shown to be tightly linked to Spna-1 on distal mouse chromosome 1. By pulsed field electrophoresis, a genomic restriction map of 6400 kb of distal mouse chromosome 1 was generated, linking genes encoding Sap, (Ifi202, Ifi203, Ifi204), and Spna-1 in that order within 450-1000 kb (where the genes within brackets were not ordered). The interferon-activated genes Ifi202, Ifi203, and Ifi204 were linked within 75-150 kb. Furthermore, genes transcriptionally activated by cytokines, namely Sap, Ifi202, Ifi203, and Ifi204, were located within 450 kb. These studies suggest the possibility that selective pressure may maintain in physical proximity gene clusters which are under coordinate transcriptional control.
AB - This report defines genetic and physical relationships among α-spectrin (Spna-1), serum amyloid P-component (Sap), and a family of interferon-activated genes, provisionally designated Ifi202, Ifi203, and Ifi204. By linkage analysis using a large panel of interspecific backcross mice, Sap, Ifi202, and Ifi204 were shown to be tightly linked to Spna-1 on distal mouse chromosome 1. By pulsed field electrophoresis, a genomic restriction map of 6400 kb of distal mouse chromosome 1 was generated, linking genes encoding Sap, (Ifi202, Ifi203, Ifi204), and Spna-1 in that order within 450-1000 kb (where the genes within brackets were not ordered). The interferon-activated genes Ifi202, Ifi203, and Ifi204 were linked within 75-150 kb. Furthermore, genes transcriptionally activated by cytokines, namely Sap, Ifi202, Ifi203, and Ifi204, were located within 450 kb. These studies suggest the possibility that selective pressure may maintain in physical proximity gene clusters which are under coordinate transcriptional control.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024420119&partnerID=8YFLogxK
U2 - 10.1007/BF02421202
DO - 10.1007/BF02421202
M3 - Article
C2 - 2476388
AN - SCOPUS:0024420119
VL - 30
SP - 169
EP - 174
JO - Immunogenetics
JF - Immunogenetics
SN - 0093-7711
IS - 3
ER -