Physical and Linkage Mapping of the Human and Murine Genes for the α1 Chain of Type IX Collagen (COL9A1)

Matthew L. Warman, George E. Tiller, Paula A. Polumbo, Michael F Seldin, Julie U. Rochelle, Joan H M Knoll, Sou De Cheng, Bjorn E. Olsen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Type IX collagen, a member of the FACIT family of extracellular matrix proteins, is a heterotrimer composed of three genetically distinct α chains. The cDNAs for the human and mouse α(IX) chains have been cloned. In this paper we confirm the mapping of the human COL9A1 gene to chromosome 6q12-q13 by fluorescence in situ hybridization utilizing two genomic clones which also contain short tandem repeat polymorphisms. We also report the characterization of these repeats and their incorporation into the chromosome 6 linkage map. The COL9A1 locus shows no recombination with the marker D6Z1 (Z = 27.61 at θ = 0) and identifies the most likely locus order of KRASIP-[D6Z1-COL9A1]-D6S30. In addition, using an interspecific backcross panel, we have mapped murine Col9a1 to mouse chromosome 1. Together with other comparative mapping results, these data suggest that the pericentric region of human chromosome 6 is homologous to the most proximal segment of mouse chromosome 1. These data may facilitate linkage studies with COL9A1 (or Col9a1 ) as a candidate gene for hereditary chondrodysplasias and osteoarthritis.

Original languageEnglish (US)
Pages (from-to)694-698
Number of pages5
JournalGenomics
Volume17
Issue number3
DOIs
StatePublished - Sep 1993
Externally publishedYes

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Collagen Type IX
Chromosome Mapping
Chromosomes, Human, Pair 6
Chromosomes, Human, Pair 1
Enchondromatosis
Genes
Extracellular Matrix Proteins
Human Chromosomes
Fluorescence In Situ Hybridization
Osteoarthritis
Microsatellite Repeats
Genetic Recombination
Complementary DNA
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • Genetics

Cite this

Warman, M. L., Tiller, G. E., Polumbo, P. A., Seldin, M. F., Rochelle, J. U., Knoll, J. H. M., ... Olsen, B. E. (1993). Physical and Linkage Mapping of the Human and Murine Genes for the α1 Chain of Type IX Collagen (COL9A1). Genomics, 17(3), 694-698. https://doi.org/10.1006/geno.1993.1391

Physical and Linkage Mapping of the Human and Murine Genes for the α1 Chain of Type IX Collagen (COL9A1). / Warman, Matthew L.; Tiller, George E.; Polumbo, Paula A.; Seldin, Michael F; Rochelle, Julie U.; Knoll, Joan H M; Cheng, Sou De; Olsen, Bjorn E.

In: Genomics, Vol. 17, No. 3, 09.1993, p. 694-698.

Research output: Contribution to journalArticle

Warman, ML, Tiller, GE, Polumbo, PA, Seldin, MF, Rochelle, JU, Knoll, JHM, Cheng, SD & Olsen, BE 1993, 'Physical and Linkage Mapping of the Human and Murine Genes for the α1 Chain of Type IX Collagen (COL9A1)', Genomics, vol. 17, no. 3, pp. 694-698. https://doi.org/10.1006/geno.1993.1391
Warman, Matthew L. ; Tiller, George E. ; Polumbo, Paula A. ; Seldin, Michael F ; Rochelle, Julie U. ; Knoll, Joan H M ; Cheng, Sou De ; Olsen, Bjorn E. / Physical and Linkage Mapping of the Human and Murine Genes for the α1 Chain of Type IX Collagen (COL9A1). In: Genomics. 1993 ; Vol. 17, No. 3. pp. 694-698.
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