Physical activity and spatial differences in medial knee T1rho and T2 relaxation times in knee osteoarthritis

Deepak Kumar, Richard B. Souza, Justin Singh, Nathaniel E. Calixto, Lorenzo Nardo, Thomas M. Link, Xiaojuan Li, Sharmila Majumdar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

•STUDY DESIGN: Cross-sectional. •OBJECTIVES: To investigate the association between knee loading-related osteoarthritis (OA) risk factors (obesity, malalignment, and physical activity) and medial knee laminar (superficial and deep) T1rho and T2 relaxation times. •BACKGROUND: The interaction of various modifiable loading-related knee risk factors and cartilage health in knee OA is currently not well known. •METHODS: Participants with and without knee OA (n = 151) underwent magnetic resonance imaging at 3 T for superficial and deep cartilage T1rho and T2 magnetic resonance relaxation times in the medial femur (MF) and medial tibia (MT). Other variables included radiographic Kellgren-Lawrence (KL) grade, alignment, pain and symptoms using the Knee injury and Osteoarthritis Outcome Score, and physical activity using the International Physical Activity Questionnaire (IPAQ). Individuals with a KL grade of 4 were excluded. Group differences were calculated using 1-way analysis of variance, adjusting for age and body mass index. Linear regression models were created with age, sex, body mass index, alignment, KL grade, and the IPAQ scores to predict the laminar T1rho and T2 times. •RESULTS: Total IPAQ scores were the only significant predictors among the loading-related variables for superficial MF T1rho (P = .005), deep MT T1rho (P = .026), and superficial MF T2 (P = .049). Additionally, the KL grade predicted the superficial MF T1rho (P = .023) and deep MT T1rho (P = .022). •CONCLUSION: Higher physical activity levels and worse radiographic severity of knee OA, but not obesity or alignment, were associated with worse cartilage composition.

Original languageEnglish (US)
Pages (from-to)964-972
Number of pages9
JournalJournal of Orthopaedic and Sports Physical Therapy
Volume44
Issue number12
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Knee Osteoarthritis
Femur
Knee
Tibia
Cartilage
Linear Models
Body Mass Index
Obesity
Knee Injuries
Osteoarthritis
Analysis of Variance
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Pain
Health
Surveys and Questionnaires

Keywords

  • Cartilage
  • IPAQ
  • KL
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Physical activity and spatial differences in medial knee T1rho and T2 relaxation times in knee osteoarthritis. / Kumar, Deepak; Souza, Richard B.; Singh, Justin; Calixto, Nathaniel E.; Nardo, Lorenzo; Link, Thomas M.; Li, Xiaojuan; Majumdar, Sharmila.

In: Journal of Orthopaedic and Sports Physical Therapy, Vol. 44, No. 12, 01.01.2014, p. 964-972.

Research output: Contribution to journalArticle

Kumar, Deepak ; Souza, Richard B. ; Singh, Justin ; Calixto, Nathaniel E. ; Nardo, Lorenzo ; Link, Thomas M. ; Li, Xiaojuan ; Majumdar, Sharmila. / Physical activity and spatial differences in medial knee T1rho and T2 relaxation times in knee osteoarthritis. In: Journal of Orthopaedic and Sports Physical Therapy. 2014 ; Vol. 44, No. 12. pp. 964-972.
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N2 - •STUDY DESIGN: Cross-sectional. •OBJECTIVES: To investigate the association between knee loading-related osteoarthritis (OA) risk factors (obesity, malalignment, and physical activity) and medial knee laminar (superficial and deep) T1rho and T2 relaxation times. •BACKGROUND: The interaction of various modifiable loading-related knee risk factors and cartilage health in knee OA is currently not well known. •METHODS: Participants with and without knee OA (n = 151) underwent magnetic resonance imaging at 3 T for superficial and deep cartilage T1rho and T2 magnetic resonance relaxation times in the medial femur (MF) and medial tibia (MT). Other variables included radiographic Kellgren-Lawrence (KL) grade, alignment, pain and symptoms using the Knee injury and Osteoarthritis Outcome Score, and physical activity using the International Physical Activity Questionnaire (IPAQ). Individuals with a KL grade of 4 were excluded. Group differences were calculated using 1-way analysis of variance, adjusting for age and body mass index. Linear regression models were created with age, sex, body mass index, alignment, KL grade, and the IPAQ scores to predict the laminar T1rho and T2 times. •RESULTS: Total IPAQ scores were the only significant predictors among the loading-related variables for superficial MF T1rho (P = .005), deep MT T1rho (P = .026), and superficial MF T2 (P = .049). Additionally, the KL grade predicted the superficial MF T1rho (P = .023) and deep MT T1rho (P = .022). •CONCLUSION: Higher physical activity levels and worse radiographic severity of knee OA, but not obesity or alignment, were associated with worse cartilage composition.

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