Physical activity and mortality in postmenopausal women

Lawrence H. Kushi, Rebecca M. Fee, Aaron R. Folsom, Pamela J. Mink, Kristin E. Anderson, Thomas A. Sellers

Research output: Contribution to journalArticle

303 Citations (Scopus)

Abstract

Objective. - To evaluate the association between physical activity and all-cause mortality in postmenopausal women. Design. - Prospective cohort study with 7 years of follow-up through December 31, 1992. Setting and Participants. - Subjects were 40 417 postmenopausal Iowa women, aged 55 to 69 years at baseline in 1986. Physical activity was assessed by mailed questionnaire. Main Outcome Measure. - All-cause mortality (n=2260). Results. - After adjustment for potential confounders and excluding women who reported having cancer or heart disease and those who died in the first 3 years of follow-up, women who reported regular physical activity were at significantly reduced risk of death during follow-up compared with women who did not (relative risk [RR], 0.77; 95% confidence interval [CI], 0.66-0.90). Increasing frequency of moderate physical activity was associated with reduced risk of death during follow-up (from rarely or never engaging in activity to activity at least 4 times per week, RRs, 1.0 [referent], 0.76, 0.70, and 0.62; P value for trend<.001). A similar pattern was seen for vigorous physical activity (corresponding RRs, 1.0, 0.89, 0.74, and 0.57; P value for trend=.06). Reduced risks of death with increased physical activity were evident for cardiovascular diseases (n=729) and respiratory illnesses (n=147). Women who engaged only in moderate but not vigorous physical activity also benefited, with moderate activity as infrequently as once per week demonstrating a reduced mortality risk of 0.78 (95% CI, 0.64-0.96). Conclusions. - These results demonstrate a graded, inverse association between physical activity and all-cause mortality in postmenopausal women. These findings strengthen the confidence that population recommendations to engage in regular physical activity are applicable to postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1287-1292
Number of pages6
JournalJournal of the American Medical Association
Volume277
Issue number16
StatePublished - Apr 23 1997
Externally publishedYes

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Exercise
Mortality
Confidence Intervals
Heart Diseases
Cohort Studies
Cardiovascular Diseases
Outcome Assessment (Health Care)
Prospective Studies
Population
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kushi, L. H., Fee, R. M., Folsom, A. R., Mink, P. J., Anderson, K. E., & Sellers, T. A. (1997). Physical activity and mortality in postmenopausal women. Journal of the American Medical Association, 277(16), 1287-1292.

Physical activity and mortality in postmenopausal women. / Kushi, Lawrence H.; Fee, Rebecca M.; Folsom, Aaron R.; Mink, Pamela J.; Anderson, Kristin E.; Sellers, Thomas A.

In: Journal of the American Medical Association, Vol. 277, No. 16, 23.04.1997, p. 1287-1292.

Research output: Contribution to journalArticle

Kushi, LH, Fee, RM, Folsom, AR, Mink, PJ, Anderson, KE & Sellers, TA 1997, 'Physical activity and mortality in postmenopausal women', Journal of the American Medical Association, vol. 277, no. 16, pp. 1287-1292.
Kushi LH, Fee RM, Folsom AR, Mink PJ, Anderson KE, Sellers TA. Physical activity and mortality in postmenopausal women. Journal of the American Medical Association. 1997 Apr 23;277(16):1287-1292.
Kushi, Lawrence H. ; Fee, Rebecca M. ; Folsom, Aaron R. ; Mink, Pamela J. ; Anderson, Kristin E. ; Sellers, Thomas A. / Physical activity and mortality in postmenopausal women. In: Journal of the American Medical Association. 1997 ; Vol. 277, No. 16. pp. 1287-1292.
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