Phylogenomic characterization of California sea lion adenovirus-1

Galaxia Cortés-Hinojosa, Frances M D Gulland, Tracey Goldstein, Stephanie Venn-Watson, Rebecca Rivera, Thomas B. Waltzek, Marco Salemi, James F X Wellehan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Significant adenoviral diversity has been found in humans, but in domestic and wild animals the number of identified viruses is lower. Here we present the complete genome of a recently discovered mastadenovirus, California sea lion adenovirus 1 (CSLAdV-1) isolated from California sea lions (. Zalophus californianus), an important pathogen associated with hepatitis in pinnipeds. The genome of this virus has the typical mastadenoviral structure with some notable differences at the carboxy-terminal end, including a dUTPase that does not cluster with other mastadenoviral dUTPases, and a fiber that shows similarity to a trans-sialidase of Trypanosoma cruzi and choline-binding protein A (CbpA) of Streptococcus pneumoniae. The GC content is low (36%), and phylogenetic analyses placed the virus near the root of the clade infecting laurasiatherian hosts in the genus Mastadenovirus. These findings support the hypothesis that CSLAdV-1 in California sea lions represents a host jump from an unknown mammalian host in which it is endemic.

Original languageEnglish (US)
Pages (from-to)270-276
Number of pages7
JournalInfection, Genetics and Evolution
Volume31
DOIs
StatePublished - Apr 1 2015

Fingerprint

Sea Lions
pinniped
Adenoviridae
Mastadenovirus
virus
Viruses
viruses
genome
Pinnipedia
Genome
hepatitis
Streptococcus pneumoniae
Wild Animals
pneumonia
sialidase
Trypanosoma cruzi
Domestic Animals
Staphylococcal Protein A
Base Composition
choline

Keywords

  • Adenovirus
  • California sea lion
  • Genome
  • Mastadenovirus
  • Phylogeny
  • Zalophus californianus

ASJC Scopus subject areas

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Cortés-Hinojosa, G., Gulland, F. M. D., Goldstein, T., Venn-Watson, S., Rivera, R., Waltzek, T. B., ... Wellehan, J. F. X. (2015). Phylogenomic characterization of California sea lion adenovirus-1. Infection, Genetics and Evolution, 31, 270-276. https://doi.org/10.1016/j.meegid.2015.01.024

Phylogenomic characterization of California sea lion adenovirus-1. / Cortés-Hinojosa, Galaxia; Gulland, Frances M D; Goldstein, Tracey; Venn-Watson, Stephanie; Rivera, Rebecca; Waltzek, Thomas B.; Salemi, Marco; Wellehan, James F X.

In: Infection, Genetics and Evolution, Vol. 31, 01.04.2015, p. 270-276.

Research output: Contribution to journalArticle

Cortés-Hinojosa, G, Gulland, FMD, Goldstein, T, Venn-Watson, S, Rivera, R, Waltzek, TB, Salemi, M & Wellehan, JFX 2015, 'Phylogenomic characterization of California sea lion adenovirus-1', Infection, Genetics and Evolution, vol. 31, pp. 270-276. https://doi.org/10.1016/j.meegid.2015.01.024
Cortés-Hinojosa, Galaxia ; Gulland, Frances M D ; Goldstein, Tracey ; Venn-Watson, Stephanie ; Rivera, Rebecca ; Waltzek, Thomas B. ; Salemi, Marco ; Wellehan, James F X. / Phylogenomic characterization of California sea lion adenovirus-1. In: Infection, Genetics and Evolution. 2015 ; Vol. 31. pp. 270-276.
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