Phylogenetic evidence for multiple Alu source genes

E. P. Leeflang, W. M. Liu, C. Hashimoto, Prabhakara V Choudary, C. W. Schmid

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

A member of the young PV Alu subfamily is detected in chimpanzee DNA showing that the PV subfamily is not specific to human DNA. This particular Alu is absent from the orthologous loci in both human and gorilla DNAs, indicating that PV subfamily members transposed within the chimpanzee lineage following the divergence of chimpanzee from both gorilla and human. These findings and previous reports describing the transpositional activity of other Alu sequences within the human, gorilla, and chimpanzee lineages provide phylogenetic evidence for the existence of multiple Alu source genes. Sequences surrounding this particular Alu resemble known transcriptional control elements associated with RNA polymerase III, suggesting a mechanism by which cis-acting elements might be acquired upon retrotransposition.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalJournal of Molecular Evolution
Volume35
Issue number1
StatePublished - 1992

Fingerprint

Pan troglodytes
Gorilla gorilla
Gorilla
Genes
phylogenetics
DNA
gene
phylogeny
RNA Polymerase III
genes
RNA
DNA-directed RNA polymerase
divergence
loci

Keywords

  • Alu source genes
  • Gorillas
  • Humans
  • Retrotransposition

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

Cite this

Leeflang, E. P., Liu, W. M., Hashimoto, C., Choudary, P. V., & Schmid, C. W. (1992). Phylogenetic evidence for multiple Alu source genes. Journal of Molecular Evolution, 35(1), 7-16.

Phylogenetic evidence for multiple Alu source genes. / Leeflang, E. P.; Liu, W. M.; Hashimoto, C.; Choudary, Prabhakara V; Schmid, C. W.

In: Journal of Molecular Evolution, Vol. 35, No. 1, 1992, p. 7-16.

Research output: Contribution to journalArticle

Leeflang, EP, Liu, WM, Hashimoto, C, Choudary, PV & Schmid, CW 1992, 'Phylogenetic evidence for multiple Alu source genes', Journal of Molecular Evolution, vol. 35, no. 1, pp. 7-16.
Leeflang EP, Liu WM, Hashimoto C, Choudary PV, Schmid CW. Phylogenetic evidence for multiple Alu source genes. Journal of Molecular Evolution. 1992;35(1):7-16.
Leeflang, E. P. ; Liu, W. M. ; Hashimoto, C. ; Choudary, Prabhakara V ; Schmid, C. W. / Phylogenetic evidence for multiple Alu source genes. In: Journal of Molecular Evolution. 1992 ; Vol. 35, No. 1. pp. 7-16.
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