Phylogenetic evidence for multiple Alu source genes

E. P. Leeflang, W. M. Liu, C. Hashimoto, Prabhakara V Choudary, C. W. Schmid

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


A member of the young PV Alu subfamily is detected in chimpanzee DNA showing that the PV subfamily is not specific to human DNA. This particular Alu is absent from the orthologous loci in both human and gorilla DNAs, indicating that PV subfamily members transposed within the chimpanzee lineage following the divergence of chimpanzee from both gorilla and human. These findings and previous reports describing the transpositional activity of other Alu sequences within the human, gorilla, and chimpanzee lineages provide phylogenetic evidence for the existence of multiple Alu source genes. Sequences surrounding this particular Alu resemble known transcriptional control elements associated with RNA polymerase III, suggesting a mechanism by which cis-acting elements might be acquired upon retrotransposition.

Original languageEnglish (US)
Pages (from-to)7-16
Number of pages10
JournalJournal of Molecular Evolution
Issue number1
StatePublished - 1992


  • Alu source genes
  • Gorillas
  • Humans
  • Retrotransposition

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)


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