Phyllodes tumor of the breast histopathologic features, differential diagnosis, and molecular/genetic updates

Yanhong Zhang, Celina G. Kleer

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Context.-Phyllodes tumor (PT) of the breast is a rare fibroepithelial neoplasm with risks of local recurrence and uncommon metastases. The classification proposed by the World Health Organization for PTs into benign, borderline, and malignant is based on a combination of several histologic features. The differential diagnosis between PT and fibroadenoma and the histologic grading of PT remain challenging. In addition, the molecular pathogenesis of PT is largely unknown. Objective.-To provide an updated overview of pathologic features, diagnostic terminology, and molecular alterations of PT. Data Sources.-Current English literature related to PT of the breast. Conclusions.-Phyllodes tumor shows a wide spectrum of morphology. There are no clearly distinct boundaries between PT and fibroadenoma. Strict histologic assessment of a combination of histologic features with classification can help to achieve the correct diagnosis and provide useful clinical information. The genomic landscapes of PT generated from genomic sequencing provide insights into the molecular pathogenesis of PT and help to improve diagnostic accuracy and identify potential drug targets in malignant PT.

Original languageEnglish (US)
Pages (from-to)665-671
Number of pages7
JournalArchives of Pathology and Laboratory Medicine
Volume140
Issue number7
DOIs
StatePublished - Jul 1 2016

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Phyllodes Tumor
Molecular Biology
Breast
Differential Diagnosis
Fibroadenoma
Fibroepithelial Neoplasms
Literature
Molecular Pathology
Information Storage and Retrieval
Terminology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Phyllodes tumor of the breast histopathologic features, differential diagnosis, and molecular/genetic updates. / Zhang, Yanhong; Kleer, Celina G.

In: Archives of Pathology and Laboratory Medicine, Vol. 140, No. 7, 01.07.2016, p. 665-671.

Research output: Contribution to journalArticle

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