Photosensitised conversion of cytosine into uracil derivatives in the presence of mercaptans

Nien Chu C Yang, Renji Okazaki, Fu-Tong Liu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Acetone sensitized photochemical reaction between cytosine and cysteine in water yields 5,6-dihydro-uracil (72%), 5-S-cysteinyl-5,6-dihydrouracil (24%), and uracil (2.2%), suggesting that radiation may cause not only crosslinking of proteins to nucleic acids but also base modifications.

Original languageEnglish (US)
Pages (from-to)462-463
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number12
DOIs
StatePublished - 1974
Externally publishedYes

Fingerprint

Uracil
Photochemical reactions
Cytosine
Nucleic acids
Sulfhydryl Compounds
Acetone
Crosslinking
Derivatives
Proteins
Radiation
Nucleic Acids
Cysteine
Water
dihydrouracil

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Photosensitised conversion of cytosine into uracil derivatives in the presence of mercaptans. / Yang, Nien Chu C; Okazaki, Renji; Liu, Fu-Tong.

In: Journal of the Chemical Society, Chemical Communications, No. 12, 1974, p. 462-463.

Research output: Contribution to journalArticle

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