PhotoPoint™ photodynamic therapy with local drug delivery eliminates vessel wall cells in arteriovenous graft models

Julie M. Burgher, Jennifer M. Barton, Michael M. Farooq, Jeff Vasek, Robert W. Scott, Julie A. Freischlag, Robert I. Grove

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Purpose: To demonstrate the feasibility of PhotoPoint photodynamic therapy (PDT) with local drug delivery, optimize dosimetry in a rabbit jugular vein model, and investigate its ability to deplete potential neointimal precursor cells in the vessel wall in a canine arteriovenous graft (AVG) model. Methods and materials: Photosensitizer MV2101 was administered locally in rabbit veins, incubated for 0-40 min and activated with external laser light. In canine veins, MV2101 was incubated for 30 min and activated by light. Tissues were excised at acute and chronic timepoints. Results: PhotoPoint PDT reduced cell populations in both models with maximum depletions occurring at 20 min (≥100 J/cm2) in rabbit veins (>90% depletion) and 30 min (200 J/cm 2) in canine veins (>85% depletion). Chronic veins revealed no evidence of PhotoPoint PDT-related abnormalities. Conclusions: PhotoPoint PDT with local MV2101 dramatically depleted potential neointimal precursor cells in the vessel wall. This suggests local drug delivery is feasible and that PhotoPoint PDT may be an efficacious treatment that could prolong AVG patency in the clinic.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalCardiovascular Radiation Medicine
Volume3
Issue number3-4
DOIs
StatePublished - Jul 2002

Keywords

  • Arteriovenous access graft
  • AVG
  • Canine
  • Intimal hyperplasia
  • Local drug administration
  • PDT
  • Photodynamic therapy
  • PhotoPoint
  • Rabbit

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

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  • Cite this

    Burgher, J. M., Barton, J. M., Farooq, M. M., Vasek, J., Scott, R. W., Freischlag, J. A., & Grove, R. I. (2002). PhotoPoint™ photodynamic therapy with local drug delivery eliminates vessel wall cells in arteriovenous graft models. Cardiovascular Radiation Medicine, 3(3-4), 163-168. https://doi.org/10.1016/S1522-1865(03)00080-5