Photo and redox dual responsive reversibly cross-linked nanocarrier for efficient tumor-targeted drug delivery

Yu Shao, Changying Shi, Gaofei Xu, Dandan Guo, Juntao Luo

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

To develop a feasible and efficient nanocarrier for potential clinical application, a series of photo and redox dual responsive reversibly cross-linked micelles have been developed for the targeted anticancer drug delivery. The nanocarrier can be cross-linked efficiently via a clean, efficient, and controllable coumarin photodimerization within the nanocarrier, which simplify the formulation process and quality control prior clinical use and improve the in vivo stability for tumor targeting. At the same time, cross-linking of nanocarrier could be cleaved via the responsiveness of the built-in disulfide cross-linkage to the redox tumor microenvironment for on-demand drug release. Coumarin and disulfide bond was introduced into a linear-dendritic copolymer (named as telodendrimer) precisely via peptide chemistry. The engineered nanocarrier possesses good drug loading capacity and stability, and exhibits a safer profile as well as similar anticancer effects compared with free drug in cell culture. The in vivo and ex vivo small animal imaging revealed the preferred tumor accumulation and the prolonged tumor residency of the payload delivered by the cross-linked micelles compared to the non-cross-linked micelles and free drug surrogate because of the increased stability.

Original languageEnglish (US)
Pages (from-to)10381-10392
Number of pages12
JournalACS Applied Materials and Interfaces
Volume6
Issue number13
DOIs
StatePublished - Jul 9 2014
Externally publishedYes

Keywords

  • cross-linking
  • drug delivery
  • dual responsive
  • micelle
  • photo sensitive
  • redox sensitive

ASJC Scopus subject areas

  • Materials Science(all)

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