Phosphorylation of the liver X receptors

Mingyi Chen, Michelle N. Bradley, Simon W. Beaven, Peter Tontonoz

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

The liver X receptors (LXRs) function as nutritional sensors for cholesterol and have important roles in lipid metabolism, glucose homeostasis, and inflammation. We provide the first evidence that LXRs are phosphorylated proteins. Mutational analysis and metabolic labeling indicate LXRα is phosphorylated on serine 198 in the hinge region. This is a consensus target for the MAPK family. A phosphorylation-deficient mutant, LXRα S198A, remains nuclear and responds to ligands like the wild-type protein. The biological significance of LXR phosphorylation remains to be elucidated but could provide a novel mechanism for the regulation of LXR signaling pathways and cellular metabolism.

Original languageEnglish (US)
Pages (from-to)4835-4841
Number of pages7
JournalFEBS Letters
Volume580
Issue number20
DOIs
StatePublished - Sep 4 2006

Fingerprint

Phosphorylation
Liver
Hinges
Lipid Metabolism
Metabolism
Labeling
Serine
Liver X Receptors
Proteins
Homeostasis
Cholesterol
Ligands
Inflammation
Glucose
Sensors

Keywords

  • Cholesterol metabolism
  • Liver X receptor
  • Phosphorylation

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Chen, M., Bradley, M. N., Beaven, S. W., & Tontonoz, P. (2006). Phosphorylation of the liver X receptors. FEBS Letters, 580(20), 4835-4841. https://doi.org/10.1016/j.febslet.2006.07.074

Phosphorylation of the liver X receptors. / Chen, Mingyi; Bradley, Michelle N.; Beaven, Simon W.; Tontonoz, Peter.

In: FEBS Letters, Vol. 580, No. 20, 04.09.2006, p. 4835-4841.

Research output: Contribution to journalArticle

Chen, M, Bradley, MN, Beaven, SW & Tontonoz, P 2006, 'Phosphorylation of the liver X receptors', FEBS Letters, vol. 580, no. 20, pp. 4835-4841. https://doi.org/10.1016/j.febslet.2006.07.074
Chen M, Bradley MN, Beaven SW, Tontonoz P. Phosphorylation of the liver X receptors. FEBS Letters. 2006 Sep 4;580(20):4835-4841. https://doi.org/10.1016/j.febslet.2006.07.074
Chen, Mingyi ; Bradley, Michelle N. ; Beaven, Simon W. ; Tontonoz, Peter. / Phosphorylation of the liver X receptors. In: FEBS Letters. 2006 ; Vol. 580, No. 20. pp. 4835-4841.
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