Phosphorylation abnormalities

NZB mice exhibit a B-cell signalling defect

Joseph Tuscano, Tom C. Hsu, Hayes McKnight, Aftab A. Ansari, M. Eric Gershwin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

NZB mice demonstrate common and consistent abnormalities in B-cell activation and signalling. One of the hallmark characteristics of lupus disease is the prevalent hypergammaglobulinaemia, composed primarily of anti-nuclear antibodies. In addition to the hyperproliferation seen in mice exhibiting disease, the B cells also demonstrate a marked degree of hyperactivity in response to B-cell receptor occupancy. This points to an intrinsic defect in the signalling pathways regulating the response to an activation event. Correspondingly, B cells of NZB mice exhibit a significant lack of phosphatase activity, both at baseline and in response to stimulation. This is directly reflected by a higher level of phosphorylation of tyrosine residues. Individually, SAPK and SHIP-1, both players in the B-cell receptor signalling cascade, are also found to be abnormally phosphorylated in the NZB mouse.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalJournal of Autoimmunity
Volume19
Issue number3
DOIs
StatePublished - Nov 2002

Fingerprint

Inbred NZB Mouse
B-Lymphocytes
Phosphorylation
Hypergammaglobulinemia
Phosphoric Monoester Hydrolases
Tyrosine
Anti-Idiotypic Antibodies

Keywords

  • B cells
  • Murine lupus
  • Phosphorylation pathways

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Phosphorylation abnormalities : NZB mice exhibit a B-cell signalling defect. / Tuscano, Joseph; Hsu, Tom C.; McKnight, Hayes; Ansari, Aftab A.; Gershwin, M. Eric.

In: Journal of Autoimmunity, Vol. 19, No. 3, 11.2002, p. 103-109.

Research output: Contribution to journalArticle

Tuscano, Joseph ; Hsu, Tom C. ; McKnight, Hayes ; Ansari, Aftab A. ; Gershwin, M. Eric. / Phosphorylation abnormalities : NZB mice exhibit a B-cell signalling defect. In: Journal of Autoimmunity. 2002 ; Vol. 19, No. 3. pp. 103-109.
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