Phosphorus-31 magnetic resonance metabolite imaging in the human body

Dieter J. Meyerhoff, Andrew A. Maudsley, Saul Schaefer, Michael W. Weiner

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

This work examines the feasibility of three-dimensional phosphorus-31 magnetic resonance spectroscopic imaging (31P MRSI) of metabolites in the human body using nonselective excitation with a single large circular surface coil for transmitting and receiving. The potential and limitations of this approach to clinical imaging are demonstrated on four selected examples: normal liver and heart, hematoma in the calf, and lymphoma in the groin. The obtained metabolite images showed anatomical detail and allowed differentiation of body organs and pathologic tissue from adjacent tissue. Three-dimensionally localized 31P spectra were reconstructed from nominal volumes of 4 to 15 cm3. These spectra showed characteristic resonances and metabolite intensity ratios for the tissue of origin demonstrating good three-dimensional localization. We conclude that surface coil 31P MRSI of body organs to map metabolite distributions is practically feasible with this approach, but due to experimental limitations, clinical utility requires technical improvements.

Original languageEnglish (US)
Pages (from-to)245-256
Number of pages12
JournalMagnetic Resonance Imaging
Volume10
Issue number2
DOIs
StatePublished - 1992

Fingerprint

metabolites
human body
Magnetic resonance
Metabolites
Human Body
Phosphorus
magnetic resonance
phosphorus
Magnetic Resonance Imaging
Imaging techniques
Tissue
organs
coils
Groin
Jetties
Hematoma
calves
Lymphoma
Medical imaging
liver

Keywords

  • Magnetic resonance, experimental
  • Magnetic resonance, phosphorus studies
  • Magnetic resonance, spectroscopy
  • Magnetic resonance, surface coils
  • Magnetic resonance, tissue characterization

ASJC Scopus subject areas

  • Biophysics
  • Clinical Biochemistry
  • Structural Biology
  • Radiology Nuclear Medicine and imaging
  • Condensed Matter Physics

Cite this

Phosphorus-31 magnetic resonance metabolite imaging in the human body. / Meyerhoff, Dieter J.; Maudsley, Andrew A.; Schaefer, Saul; Weiner, Michael W.

In: Magnetic Resonance Imaging, Vol. 10, No. 2, 1992, p. 245-256.

Research output: Contribution to journalArticle

Meyerhoff, Dieter J. ; Maudsley, Andrew A. ; Schaefer, Saul ; Weiner, Michael W. / Phosphorus-31 magnetic resonance metabolite imaging in the human body. In: Magnetic Resonance Imaging. 1992 ; Vol. 10, No. 2. pp. 245-256.
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