Phospholipase C β4 is involved in modulating the visual response in mice

Huiping Jiang, Arkady Lyubarsky, Robert Dodd, Noga Vardi, Edward N Pugh Jr, Denis Baylor, Melvin I. Simon, Dianqing Wu

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Expression of G protein-regulated phospholipase C (PLC) β4 in the retina, lateral geniculate nucleus, and superior colliculus implies that PLC β4 may play a role in the mammalian visual process. A mouse line that lacks PLC β4 was generated and the physiological significance of PLC β4 in murine visual function was investigated. Behavioral tests using a shuttle box demonstrated that the mice lacking PLC β4 were impaired in their visual processing abilities, whereas they showed no deficit in their auditory abilities. In addition, the PLC β-null mice showed 4-fold reduction in the maximal amplitude of the rod a- and b-wave components of their electroretinograms relative to their littermate controls. However, recording from single rod photoreceptors did not reveal any significant differences between the PLC β4-null and wild-type littermates, nor were there any apparent differences in retinas examined with light microscopy. While the behavioral and electroretinographic results indicate that PLC β4 plays a significant rule in mammalian visual signal processing, isolated rod recording shows little or no apparent deficit, suggesting that the effect of PLC β4 deficiency on the rod signaling pathway occurs at some stage after the initial phototransduction cascade and may require cell-cell interactions between rods and other retinal cells.

Original languageEnglish (US)
Pages (from-to)14598-14601
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number25
StatePublished - Dec 10 1996
Externally publishedYes


  • animal behavior
  • retinal function
  • transgenic mice
  • vision
  • visual response

ASJC Scopus subject areas

  • Genetics
  • General


Dive into the research topics of 'Phospholipase C β4 is involved in modulating the visual response in mice'. Together they form a unique fingerprint.

Cite this