Phosphoinositides regulate ion channels

Bertil Hille, Eamonn J Dickson, Martin Kruse, Oscar Vivas, Byung Chang Suh

Research output: Contribution to journalArticlepeer-review

193 Scopus citations


Abstract Phosphoinositides serve as signature motifs for different cellular membranes and often are required for the function of membrane proteins. Here, we summarize clear evidence supporting the concept that many ion channels are regulated by membrane phosphoinositides. We describe tools used to test their dependence on phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, and consider mechanisms and biological meanings of phosphoinositide regulation of ion channels. This lipid regulation can underlie changes of channel activity and electrical excitability in response to receptors. Since different intracellular membranes have different lipid compositions, the activity of ion channels still in transit towards their final destination membrane may be suppressed until they reach an optimal lipid environment. This article is part of a Special Issue entitled Phosphoinositides.

Original languageEnglish (US)
Article number57689
Pages (from-to)844-856
Number of pages13
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Issue number6
StatePublished - 2015
Externally publishedYes


  • Calcium channel
  • G-protein coupled receptor (GPCR)
  • Phosphatidylinositol 4,5-bisphosphate
  • Phospholipase C (PLC)
  • Potassium channel
  • Transient receptor potential channel (TRP channel)

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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