Phosphoinositide transport and metabolism at membrane contact sites

Research output: Contribution to journalReview articlepeer-review

Abstract

Phosphoinositides are a family of signaling lipids that play a profound role in regulating protein function at the membrane-cytosol interface of all cellular membranes. Underscoring their importance, mutations or alterations in phosphoinositide metabolizing enzymes lead to host of developmental, neurodegenerative, and metabolic disorders that are devastating for human health. In addition to lipid enzymes, phosphoinositide metabolism is regulated and controlled at membrane contact sites (MCS). Regions of close opposition typically between the ER and other cellular membranes, MCS are non-vesicular lipid transport portals that engage in extensive communication to influence organelle homeostasis. This review focuses on lipid transport, specifically phosphoinositide lipid transport and metabolism at MCS.

Original languageEnglish (US)
Article number159107
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1867
Issue number3
DOIs
StatePublished - Mar 2022
Externally publishedYes

Keywords

  • Cholesterol
  • Extended-synaptotagmins
  • K2
  • Lipid transfer
  • Membrane contact sites
  • OSBP
  • Phosphoinositides
  • PI
  • PI(4)P
  • PI(4,5)P
  • TMEM24

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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