Phocine distemper Virus: Current knowledge and future directions

Pádraig J. Duignan, Marie Françoise Van Bressem, Jason D. Baker, Michelle Barbieri, Kathleen M. Colegrove, Sylvain de Guise, Rik L. de Swart, Giovanni di Guardo, Andrew Dobson, W. Paul Duprex, Greg Early, Deborah Fauquier, Tracey Goldstein, Simon J. Goodman, Bryan Grenfell, Kátia R. Groch, Frances Gulland, Ailsa Hall, Brenda A. Jensen, Karina LamyKeith Matassa, Sandro Mazzariol, Sinead E. Morris, Ole Nielsen, David Rotstein, Teresa K. Rowles, Jeremy T. Saliki, Ursula Siebert, Thomas Waltzek, James F X Wellehan

Research output: Contribution to journalReview article

35 Citations (Scopus)

Abstract

Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.

Original languageEnglish (US)
Pages (from-to)5093-5134
Number of pages42
JournalViruses
Volume6
Issue number12
DOIs
StatePublished - Dec 22 2014

Fingerprint

Phocine Distemper Virus
Phoca
Earless Seals
Pinnipedia
Morbillivirus
Infection
Otters
Viruses
Mortality
Prednisolone
Disease Outbreaks
Epidemiology
Vaccines
Direction compound
Population

Keywords

  • CD150/SLAM
  • Epidemiology
  • Immunity
  • Morbillivirus
  • Pathology
  • Phylogeny
  • Pinnipeds
  • Sea otter
  • Vaccine

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology
  • Medicine(all)

Cite this

Duignan, P. J., Van Bressem, M. F., Baker, J. D., Barbieri, M., Colegrove, K. M., de Guise, S., ... Wellehan, J. F. X. (2014). Phocine distemper Virus: Current knowledge and future directions. Viruses, 6(12), 5093-5134. https://doi.org/10.3390/v6125093

Phocine distemper Virus : Current knowledge and future directions. / Duignan, Pádraig J.; Van Bressem, Marie Françoise; Baker, Jason D.; Barbieri, Michelle; Colegrove, Kathleen M.; de Guise, Sylvain; de Swart, Rik L.; di Guardo, Giovanni; Dobson, Andrew; Duprex, W. Paul; Early, Greg; Fauquier, Deborah; Goldstein, Tracey; Goodman, Simon J.; Grenfell, Bryan; Groch, Kátia R.; Gulland, Frances; Hall, Ailsa; Jensen, Brenda A.; Lamy, Karina; Matassa, Keith; Mazzariol, Sandro; Morris, Sinead E.; Nielsen, Ole; Rotstein, David; Rowles, Teresa K.; Saliki, Jeremy T.; Siebert, Ursula; Waltzek, Thomas; Wellehan, James F X.

In: Viruses, Vol. 6, No. 12, 22.12.2014, p. 5093-5134.

Research output: Contribution to journalReview article

Duignan, PJ, Van Bressem, MF, Baker, JD, Barbieri, M, Colegrove, KM, de Guise, S, de Swart, RL, di Guardo, G, Dobson, A, Duprex, WP, Early, G, Fauquier, D, Goldstein, T, Goodman, SJ, Grenfell, B, Groch, KR, Gulland, F, Hall, A, Jensen, BA, Lamy, K, Matassa, K, Mazzariol, S, Morris, SE, Nielsen, O, Rotstein, D, Rowles, TK, Saliki, JT, Siebert, U, Waltzek, T & Wellehan, JFX 2014, 'Phocine distemper Virus: Current knowledge and future directions', Viruses, vol. 6, no. 12, pp. 5093-5134. https://doi.org/10.3390/v6125093
Duignan PJ, Van Bressem MF, Baker JD, Barbieri M, Colegrove KM, de Guise S et al. Phocine distemper Virus: Current knowledge and future directions. Viruses. 2014 Dec 22;6(12):5093-5134. https://doi.org/10.3390/v6125093
Duignan, Pádraig J. ; Van Bressem, Marie Françoise ; Baker, Jason D. ; Barbieri, Michelle ; Colegrove, Kathleen M. ; de Guise, Sylvain ; de Swart, Rik L. ; di Guardo, Giovanni ; Dobson, Andrew ; Duprex, W. Paul ; Early, Greg ; Fauquier, Deborah ; Goldstein, Tracey ; Goodman, Simon J. ; Grenfell, Bryan ; Groch, Kátia R. ; Gulland, Frances ; Hall, Ailsa ; Jensen, Brenda A. ; Lamy, Karina ; Matassa, Keith ; Mazzariol, Sandro ; Morris, Sinead E. ; Nielsen, Ole ; Rotstein, David ; Rowles, Teresa K. ; Saliki, Jeremy T. ; Siebert, Ursula ; Waltzek, Thomas ; Wellehan, James F X. / Phocine distemper Virus : Current knowledge and future directions. In: Viruses. 2014 ; Vol. 6, No. 12. pp. 5093-5134.
@article{13b7060fe99c402788e489d6abfd6e2f,
title = "Phocine distemper Virus: Current knowledge and future directions",
abstract = "Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.",
keywords = "CD150/SLAM, Epidemiology, Immunity, Morbillivirus, Pathology, Phylogeny, Pinnipeds, Sea otter, Vaccine",
author = "Duignan, {P{\'a}draig J.} and {Van Bressem}, {Marie Fran{\cc}oise} and Baker, {Jason D.} and Michelle Barbieri and Colegrove, {Kathleen M.} and {de Guise}, Sylvain and {de Swart}, {Rik L.} and {di Guardo}, Giovanni and Andrew Dobson and Duprex, {W. Paul} and Greg Early and Deborah Fauquier and Tracey Goldstein and Goodman, {Simon J.} and Bryan Grenfell and Groch, {K{\'a}tia R.} and Frances Gulland and Ailsa Hall and Jensen, {Brenda A.} and Karina Lamy and Keith Matassa and Sandro Mazzariol and Morris, {Sinead E.} and Ole Nielsen and David Rotstein and Rowles, {Teresa K.} and Saliki, {Jeremy T.} and Ursula Siebert and Thomas Waltzek and Wellehan, {James F X}",
year = "2014",
month = "12",
day = "22",
doi = "10.3390/v6125093",
language = "English (US)",
volume = "6",
pages = "5093--5134",
journal = "Viruses",
issn = "1999-4915",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",

}

TY - JOUR

T1 - Phocine distemper Virus

T2 - Current knowledge and future directions

AU - Duignan, Pádraig J.

AU - Van Bressem, Marie Françoise

AU - Baker, Jason D.

AU - Barbieri, Michelle

AU - Colegrove, Kathleen M.

AU - de Guise, Sylvain

AU - de Swart, Rik L.

AU - di Guardo, Giovanni

AU - Dobson, Andrew

AU - Duprex, W. Paul

AU - Early, Greg

AU - Fauquier, Deborah

AU - Goldstein, Tracey

AU - Goodman, Simon J.

AU - Grenfell, Bryan

AU - Groch, Kátia R.

AU - Gulland, Frances

AU - Hall, Ailsa

AU - Jensen, Brenda A.

AU - Lamy, Karina

AU - Matassa, Keith

AU - Mazzariol, Sandro

AU - Morris, Sinead E.

AU - Nielsen, Ole

AU - Rotstein, David

AU - Rowles, Teresa K.

AU - Saliki, Jeremy T.

AU - Siebert, Ursula

AU - Waltzek, Thomas

AU - Wellehan, James F X

PY - 2014/12/22

Y1 - 2014/12/22

N2 - Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.

AB - Phocine distemper virus (PDV) was first recognized in 1988 following a massive epidemic in harbor and grey seals in north-western Europe. Since then, the epidemiology of infection in North Atlantic and Arctic pinnipeds has been investigated. In the western North Atlantic endemic infection in harp and grey seals predates the European epidemic, with relatively small, localized mortality events occurring primarily in harbor seals. By contrast, PDV seems not to have become established in European harbor seals following the 1988 epidemic and a second event of similar magnitude and extent occurred in 2002. PDV is a distinct species within the Morbillivirus genus with minor sequence variation between outbreaks over time. There is now mounting evidence of PDV-like viruses in the North Pacific/Western Arctic with serological and molecular evidence of infection in pinnipeds and sea otters. However, despite the absence of associated mortality in the region, there is concern that the virus may infect the large Pacific harbor seal and northern elephant seal populations or the endangered Hawaiian monk seals. Here, we review the current state of knowledge on PDV with particular focus on developments in diagnostics, pathogenesis, immune response, vaccine development, phylogenetics and modeling over the past 20 years.

KW - CD150/SLAM

KW - Epidemiology

KW - Immunity

KW - Morbillivirus

KW - Pathology

KW - Phylogeny

KW - Pinnipeds

KW - Sea otter

KW - Vaccine

UR - http://www.scopus.com/inward/record.url?scp=84919819797&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919819797&partnerID=8YFLogxK

U2 - 10.3390/v6125093

DO - 10.3390/v6125093

M3 - Review article

C2 - 25533658

AN - SCOPUS:84919819797

VL - 6

SP - 5093

EP - 5134

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 12

ER -