Phenotypic and functional status of intrahepatic T cells in chronic hepatitis C

Jinhui Wang, Tyson H. Holmes, Laura Ladron De Guevara, Ramsey Cheung, Teresa L. Wright, Xiaosong He, Harry B. Greenberg

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Polychromatic flow-cytometric assays were used to analyze paired intrahepatic and peripheral lymphocyte samples from 37 patients with chronic hepatitis C. Compared with peripheral cells, intrahepatic T cells were selectively enriched with CD45RO+ memory T cells but had a lower percentage of CD4+ T cells expressing the differentiation markers CD27 and CD28. The percentage of intrahepatic CD45RO+ and CD28 + T cells correlated with the degree of liver inflammation, which suggests that memory T cells at relatively early stages of differentiation are directly involved in liver inflammation. Despite their memory phenotype, intrahepatic T cells were defective in proliferation capability, produced less interferon-γ in response to stimulation by T cell receptor, and contained less perforin but expressed higher levels of Fas and Fas ligand, compared with their counterparts in peripheral blood. The distinct characteristics of intrahepatic T cells suggest that they play an important role in the immunopathogenesis of chronic hepatitis C.

Original languageEnglish (US)
Pages (from-to)1068-1077
Number of pages10
JournalJournal of Infectious Diseases
Volume194
Issue number8
DOIs
StatePublished - Oct 15 2006
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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    Wang, J., Holmes, T. H., Ladron De Guevara, L., Cheung, R., Wright, T. L., He, X., & Greenberg, H. B. (2006). Phenotypic and functional status of intrahepatic T cells in chronic hepatitis C. Journal of Infectious Diseases, 194(8), 1068-1077. https://doi.org/10.1086/507681