Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice

Claire Pomeroy, Lisa Miller, Lynn McFarling, Cynthia Kennedy, Gregory A. Filice

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Toxoplasma gondii pneumonia has emerged as an important problem in immunocompromised patients, especially those with AIDS. The characteristics of lung lymphocytes, including their phenotypes, proliferative responses, and suppressor function during T. gondii pneumonia were studied. During primary acute T. gondii infection, the numbers of T lymphocytes in the lungs increased even though mice lacked histologic evidence of pneumonia. As mice recovered from acute toxoplasmosis, numbers of lung CD4+ cells and the ratio of CD4+ to CD8+ cells decreased. Subsequently, T. gondii infection reactivated, manifested as pneumonia. During pneumonia, lung T lymphocytes, especially CD8+ cells, increased even more. Lung lymphocytes from mice with T. gondii pneumonia decreased the proliferative responses of splenocytes from T. gondii-immune mice to both concanavalin A and T. gondii lysate antigens in vitro. The striking increase in lung CD8+ cells and suppressor activity appear to be integral to the pathogenesis of T. gondii pneumonia.

Original languageEnglish (US)
Pages (from-to)1227-1232
Number of pages6
JournalJournal of Infectious Diseases
Volume164
Issue number6
StatePublished - Dec 1991
Externally publishedYes

Fingerprint

Toxoplasma
Pneumonia
Lymphocytes
Phenotype
Lung
Toxoplasmosis
T-Lymphocytes
CD4-CD8 Ratio
Immunocompromised Host
Concanavalin A
Acquired Immunodeficiency Syndrome
Antigens

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice. / Pomeroy, Claire; Miller, Lisa; McFarling, Lynn; Kennedy, Cynthia; Filice, Gregory A.

In: Journal of Infectious Diseases, Vol. 164, No. 6, 12.1991, p. 1227-1232.

Research output: Contribution to journalArticle

Pomeroy, C, Miller, L, McFarling, L, Kennedy, C & Filice, GA 1991, 'Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice', Journal of Infectious Diseases, vol. 164, no. 6, pp. 1227-1232.
Pomeroy, Claire ; Miller, Lisa ; McFarling, Lynn ; Kennedy, Cynthia ; Filice, Gregory A. / Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice. In: Journal of Infectious Diseases. 1991 ; Vol. 164, No. 6. pp. 1227-1232.
@article{8e87e2497610409fb527c9d445da9d7f,
title = "Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice",
abstract = "Toxoplasma gondii pneumonia has emerged as an important problem in immunocompromised patients, especially those with AIDS. The characteristics of lung lymphocytes, including their phenotypes, proliferative responses, and suppressor function during T. gondii pneumonia were studied. During primary acute T. gondii infection, the numbers of T lymphocytes in the lungs increased even though mice lacked histologic evidence of pneumonia. As mice recovered from acute toxoplasmosis, numbers of lung CD4+ cells and the ratio of CD4+ to CD8+ cells decreased. Subsequently, T. gondii infection reactivated, manifested as pneumonia. During pneumonia, lung T lymphocytes, especially CD8+ cells, increased even more. Lung lymphocytes from mice with T. gondii pneumonia decreased the proliferative responses of splenocytes from T. gondii-immune mice to both concanavalin A and T. gondii lysate antigens in vitro. The striking increase in lung CD8+ cells and suppressor activity appear to be integral to the pathogenesis of T. gondii pneumonia.",
author = "Claire Pomeroy and Lisa Miller and Lynn McFarling and Cynthia Kennedy and Filice, {Gregory A.}",
year = "1991",
month = "12",
language = "English (US)",
volume = "164",
pages = "1227--1232",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",

}

TY - JOUR

T1 - Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice

AU - Pomeroy, Claire

AU - Miller, Lisa

AU - McFarling, Lynn

AU - Kennedy, Cynthia

AU - Filice, Gregory A.

PY - 1991/12

Y1 - 1991/12

N2 - Toxoplasma gondii pneumonia has emerged as an important problem in immunocompromised patients, especially those with AIDS. The characteristics of lung lymphocytes, including their phenotypes, proliferative responses, and suppressor function during T. gondii pneumonia were studied. During primary acute T. gondii infection, the numbers of T lymphocytes in the lungs increased even though mice lacked histologic evidence of pneumonia. As mice recovered from acute toxoplasmosis, numbers of lung CD4+ cells and the ratio of CD4+ to CD8+ cells decreased. Subsequently, T. gondii infection reactivated, manifested as pneumonia. During pneumonia, lung T lymphocytes, especially CD8+ cells, increased even more. Lung lymphocytes from mice with T. gondii pneumonia decreased the proliferative responses of splenocytes from T. gondii-immune mice to both concanavalin A and T. gondii lysate antigens in vitro. The striking increase in lung CD8+ cells and suppressor activity appear to be integral to the pathogenesis of T. gondii pneumonia.

AB - Toxoplasma gondii pneumonia has emerged as an important problem in immunocompromised patients, especially those with AIDS. The characteristics of lung lymphocytes, including their phenotypes, proliferative responses, and suppressor function during T. gondii pneumonia were studied. During primary acute T. gondii infection, the numbers of T lymphocytes in the lungs increased even though mice lacked histologic evidence of pneumonia. As mice recovered from acute toxoplasmosis, numbers of lung CD4+ cells and the ratio of CD4+ to CD8+ cells decreased. Subsequently, T. gondii infection reactivated, manifested as pneumonia. During pneumonia, lung T lymphocytes, especially CD8+ cells, increased even more. Lung lymphocytes from mice with T. gondii pneumonia decreased the proliferative responses of splenocytes from T. gondii-immune mice to both concanavalin A and T. gondii lysate antigens in vitro. The striking increase in lung CD8+ cells and suppressor activity appear to be integral to the pathogenesis of T. gondii pneumonia.

UR - http://www.scopus.com/inward/record.url?scp=0025876225&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025876225&partnerID=8YFLogxK

M3 - Article

VL - 164

SP - 1227

EP - 1232

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 6

ER -