Phenotypes, proliferative responses, and suppressor function of lung lymphocytes during Toxoplasma gondii pneumonia in mice

Claire Pomeroy, Lisa Miller, Lynn McFarling, Cynthia Kennedy, Gregory A. Filice

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Toxoplasma gondii pneumonia has emerged as an important problem in immunocompromised patients, especially those with AIDS. The characteristics of lung lymphocytes, including their phenotypes, proliferative responses, and suppressor function during T. gondii pneumonia were studied. During primary acute T. gondii infection, the numbers of T lymphocytes in the lungs increased even though mice lacked histologic evidence of pneumonia. As mice recovered from acute toxoplasmosis, numbers of lung CD4+ cells and the ratio of CD4+ to CD8+ cells decreased. Subsequently, T. gondii infection reactivated, manifested as pneumonia. During pneumonia, lung T lymphocytes, especially CD8+ cells, increased even more. Lung lymphocytes from mice with T. gondii pneumonia decreased the proliferative responses of splenocytes from T. gondii-immune mice to both concanavalin A and T. gondii lysate antigens in vitro. The striking increase in lung CD8+ cells and suppressor activity appear to be integral to the pathogenesis of T. gondii pneumonia.

Original languageEnglish (US)
Pages (from-to)1227-1232
Number of pages6
JournalJournal of Infectious Diseases
Volume164
Issue number6
StatePublished - Dec 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

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