Phase-transition based transduction in a biosensor

J. F. Bardeau, A. S. Eberhardt, R. M. Nyquist, A. N. Parikh, A. P. Shreve, B. I. Swanson

Research output: Contribution to journalArticle

1 Scopus citations


Shifts in the main phase transition temperatures caused by a highly specific, protein-receptor interaction in a hybrid bilayer architecture are probed utilizing temperature programmed infrared vibrational spectroscopy. The specific case of cholera toxin attachment to glycolipid receptors embedded in a phospholipid outer layer at a hydrophobized silicon surface is investigated. Potential applications of the approach as a signal amplification method in biosensors will be discussed.

Original languageEnglish (US)
Pages (from-to)1452-1453
Number of pages2
JournalSynthetic Metals
Issue number1-3
StatePublished - Jun 1999
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Polymers and Plastics

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    Bardeau, J. F., Eberhardt, A. S., Nyquist, R. M., Parikh, A. N., Shreve, A. P., & Swanson, B. I. (1999). Phase-transition based transduction in a biosensor. Synthetic Metals, 102(1-3), 1452-1453.