Phase-transition based transduction in a biosensor

J. F. Bardeau, A. S. Eberhardt, R. M. Nyquist, A. N. Parikh, A. P. Shreve, B. I. Swanson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Shifts in the main phase transition temperatures caused by a highly specific, protein-receptor interaction in a hybrid bilayer architecture are probed utilizing temperature programmed infrared vibrational spectroscopy. The specific case of cholera toxin attachment to glycolipid receptors embedded in a phospholipid outer layer at a hydrophobized silicon surface is investigated. Potential applications of the approach as a signal amplification method in biosensors will be discussed.

Original languageEnglish (US)
Pages (from-to)1452-1453
Number of pages2
JournalSynthetic Metals
Issue number1-3
StatePublished - Jun 1999
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Polymers and Plastics


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