Phase I study of paclitaxel with oral etoposide in advanced solid tumors

Edith A. Perez, Tracy Coe, Corinne Turrell, Derick Lau, David Campbell, David Gandara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE: This study evaluated dose escalation of paclitaxel administered as a 3-hour infusion after a fixed oral etoposide regimen given daily for 10 days to determine an optimal dose and a toxicity profile for this combination. PATIENTS AND METHODS: Three consecutive cohorts consisting of 29 patients with measurable or assessable advanced solid tumors were treated with paclitaxel by intravenous infusion over 3 hours after receiving etoposide, 50 mg orally twice daily, for 10 days. Cycles were repeated every 28 days. Paclitaxel dose levels were: cohort 1, 135 mg/m2; cohort 2, 150 mg/m2; and cohort 3, 175 mg/m2. RESULTS: Dose-limiting toxicity was observed in cohort 3 in 5 of 12 patients (4 of 12 patients met criteria for myelosuppression and 1 of 12 experienced grade 3 mucositis). No unexpected toxicities were observed, and this regimen was well tolerated. DISCUSSION: Administration of paclitaxel in combination with a prolonged oral schedule of etoposide is feasible and toxicities are manageable. The dose-limiting toxicity of a 3-hour infusion of paclitaxel after 10 days of etoposide given orally was myelosuppression. Recommended doses of this combination for phase II studies are etoposide, 100 mg orally daily for 10 days, followed by paclitaxel at a dose of 150 mg/m2 intravenously over 3 hours, and repeated every 4 weeks.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalCancer Journal from Scientific American
Volume2
Issue number5
StatePublished - 1996

Fingerprint

Etoposide
Paclitaxel
Neoplasms
Mucositis
Intravenous Infusions
Appointments and Schedules

Keywords

  • Etoposide
  • Paclitaxel
  • Phase I study
  • Solid tumors

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Phase I study of paclitaxel with oral etoposide in advanced solid tumors. / Perez, Edith A.; Coe, Tracy; Turrell, Corinne; Lau, Derick; Campbell, David; Gandara, David.

In: Cancer Journal from Scientific American, Vol. 2, No. 5, 1996, p. 286-290.

Research output: Contribution to journalArticle

Perez, Edith A. ; Coe, Tracy ; Turrell, Corinne ; Lau, Derick ; Campbell, David ; Gandara, David. / Phase I study of paclitaxel with oral etoposide in advanced solid tumors. In: Cancer Journal from Scientific American. 1996 ; Vol. 2, No. 5. pp. 286-290.
@article{83b8f490039e4242b9772a2ed8bebeaa,
title = "Phase I study of paclitaxel with oral etoposide in advanced solid tumors",
abstract = "PURPOSE: This study evaluated dose escalation of paclitaxel administered as a 3-hour infusion after a fixed oral etoposide regimen given daily for 10 days to determine an optimal dose and a toxicity profile for this combination. PATIENTS AND METHODS: Three consecutive cohorts consisting of 29 patients with measurable or assessable advanced solid tumors were treated with paclitaxel by intravenous infusion over 3 hours after receiving etoposide, 50 mg orally twice daily, for 10 days. Cycles were repeated every 28 days. Paclitaxel dose levels were: cohort 1, 135 mg/m2; cohort 2, 150 mg/m2; and cohort 3, 175 mg/m2. RESULTS: Dose-limiting toxicity was observed in cohort 3 in 5 of 12 patients (4 of 12 patients met criteria for myelosuppression and 1 of 12 experienced grade 3 mucositis). No unexpected toxicities were observed, and this regimen was well tolerated. DISCUSSION: Administration of paclitaxel in combination with a prolonged oral schedule of etoposide is feasible and toxicities are manageable. The dose-limiting toxicity of a 3-hour infusion of paclitaxel after 10 days of etoposide given orally was myelosuppression. Recommended doses of this combination for phase II studies are etoposide, 100 mg orally daily for 10 days, followed by paclitaxel at a dose of 150 mg/m2 intravenously over 3 hours, and repeated every 4 weeks.",
keywords = "Etoposide, Paclitaxel, Phase I study, Solid tumors",
author = "Perez, {Edith A.} and Tracy Coe and Corinne Turrell and Derick Lau and David Campbell and David Gandara",
year = "1996",
language = "English (US)",
volume = "2",
pages = "286--290",
journal = "Cancer journal (Sudbury, Mass.)",
issn = "1528-9117",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Phase I study of paclitaxel with oral etoposide in advanced solid tumors

AU - Perez, Edith A.

AU - Coe, Tracy

AU - Turrell, Corinne

AU - Lau, Derick

AU - Campbell, David

AU - Gandara, David

PY - 1996

Y1 - 1996

N2 - PURPOSE: This study evaluated dose escalation of paclitaxel administered as a 3-hour infusion after a fixed oral etoposide regimen given daily for 10 days to determine an optimal dose and a toxicity profile for this combination. PATIENTS AND METHODS: Three consecutive cohorts consisting of 29 patients with measurable or assessable advanced solid tumors were treated with paclitaxel by intravenous infusion over 3 hours after receiving etoposide, 50 mg orally twice daily, for 10 days. Cycles were repeated every 28 days. Paclitaxel dose levels were: cohort 1, 135 mg/m2; cohort 2, 150 mg/m2; and cohort 3, 175 mg/m2. RESULTS: Dose-limiting toxicity was observed in cohort 3 in 5 of 12 patients (4 of 12 patients met criteria for myelosuppression and 1 of 12 experienced grade 3 mucositis). No unexpected toxicities were observed, and this regimen was well tolerated. DISCUSSION: Administration of paclitaxel in combination with a prolonged oral schedule of etoposide is feasible and toxicities are manageable. The dose-limiting toxicity of a 3-hour infusion of paclitaxel after 10 days of etoposide given orally was myelosuppression. Recommended doses of this combination for phase II studies are etoposide, 100 mg orally daily for 10 days, followed by paclitaxel at a dose of 150 mg/m2 intravenously over 3 hours, and repeated every 4 weeks.

AB - PURPOSE: This study evaluated dose escalation of paclitaxel administered as a 3-hour infusion after a fixed oral etoposide regimen given daily for 10 days to determine an optimal dose and a toxicity profile for this combination. PATIENTS AND METHODS: Three consecutive cohorts consisting of 29 patients with measurable or assessable advanced solid tumors were treated with paclitaxel by intravenous infusion over 3 hours after receiving etoposide, 50 mg orally twice daily, for 10 days. Cycles were repeated every 28 days. Paclitaxel dose levels were: cohort 1, 135 mg/m2; cohort 2, 150 mg/m2; and cohort 3, 175 mg/m2. RESULTS: Dose-limiting toxicity was observed in cohort 3 in 5 of 12 patients (4 of 12 patients met criteria for myelosuppression and 1 of 12 experienced grade 3 mucositis). No unexpected toxicities were observed, and this regimen was well tolerated. DISCUSSION: Administration of paclitaxel in combination with a prolonged oral schedule of etoposide is feasible and toxicities are manageable. The dose-limiting toxicity of a 3-hour infusion of paclitaxel after 10 days of etoposide given orally was myelosuppression. Recommended doses of this combination for phase II studies are etoposide, 100 mg orally daily for 10 days, followed by paclitaxel at a dose of 150 mg/m2 intravenously over 3 hours, and repeated every 4 weeks.

KW - Etoposide

KW - Paclitaxel

KW - Phase I study

KW - Solid tumors

UR - http://www.scopus.com/inward/record.url?scp=0009703696&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0009703696&partnerID=8YFLogxK

M3 - Article

C2 - 9166546

AN - SCOPUS:0009703696

VL - 2

SP - 286

EP - 290

JO - Cancer journal (Sudbury, Mass.)

JF - Cancer journal (Sudbury, Mass.)

SN - 1528-9117

IS - 5

ER -