Phase I study of antilipopolysaccharide human monoclonal antibody MAB-T88

R. Daifuku, K. Haenftling, J. Young, E. S. Groves, C. Turrell, Frederick J Meyers

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Monoclonal antibody MAB-T88 is a human monoclonal immunoglobulin M antibody directed at the lipopolysaccharide of gram-negative bacteria. In this study, nine patients who were expected to become neutropenic from antineoplastic chemotherapy received an infusion of MAB-T88, three patients at each of three doses: 1, 4, and 8 mg/kg of body weight. MAB-T88 was shown to be safe, with an effective half-life in plasma of 25.4 h, and no patient developed immunoglobulin G antibody to MAB-T88.

Original languageEnglish (US)
Pages (from-to)2349-2351
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Issue number10
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)


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