Phase-based regional oxygen metabolism (PROM) using MRI

Audrey P. Fan, Thomas Benner, Divya S. Bolar, Bruce R. Rosen, Elfar Adalsteinsson

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Venous oxygen saturation (Yv) in cerebral veins and the cerebral metabolic rate of oxygen (CMRO2) are important indicators for brain function and disease. Although MRI has been used for global measurements of these parameters, currently there is no recognized technique to quantify regional Yv and CMRO2 using noninvasive imaging. This article proposes a technique to quantify CMRO2 from independent MRI estimates of Yv and cerebral blood flow. The approach uses standard gradient-echo and arterial spin labeling acquisitions to make these measurements. Using MR susceptometry on gradient-echo phase images, Y v was quantified for candidate vein segments in gray matter that approximate a long cylinder parallel to the main magnetic field. Local cerebral blood flow for the identified vessel was determined from a corresponding region in the arterial spin labeling perfusion map. Fick's principle of arteriovenous difference was then used to quantify CMRO2 locally around each vessel. Application of this method in young, healthy subjects provided gray matter averages of 59.6% ± 2.3% for Yv, 51.7 ± 6.4 mL/100 g/min for cerebral blood flow, and 158 ± 18 μmol/100 g/min for CMRO2 (mean ± SD, n = 12), which is consistent with values previously reported by positron emission tomography and MRI.

Original languageEnglish (US)
Pages (from-to)669-678
Number of pages10
JournalMagnetic Resonance in Medicine
Volume67
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Keywords

  • cerebral blood flow
  • cerebral metabolic rate of oxygen
  • cerebral venous oxygen saturation
  • MR susceptometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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