Pharmacotherapy for Pulmonary Hypertension

Robin H Steinhorn

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

Original languageEnglish (US)
Pages (from-to)1130-1146
Number of pages17
JournalPediatric Clinics of North America
Volume59
Issue number5
DOIs
StatePublished - Oct 2012
Externally publishedYes

Keywords

  • Endothelin
  • Nitric oxide
  • Phosphodiesterase
  • Prostacyclin
  • Pulmonary hypertension
  • Pulmonary vasculature
  • Vasodilator

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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