Pharmacotherapy for Pulmonary Hypertension

Robin H Steinhorn

doi:10.1016/j.pcl.2012.07.011

Pharmacotherapy for Pulmonary Hypertension

Robin H Steinhorn

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

Original language	English (US)
Pages (from-to)	1130-1146
Number of pages	17
Journal	Pediatric Clinics of North America
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/j.pcl.2012.07.011
State	Published - Oct 2012
Externally published	Yes

Keywords

Endothelin
Nitric oxide
Phosphodiesterase
Prostacyclin
Pulmonary hypertension
Pulmonary vasculature
Vasodilator

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

Access to Document

10.1016/j.pcl.2012.07.011

Cite this

@article{2d9dc422e1834cbead0499163d089d95,

title = "Pharmacotherapy for Pulmonary Hypertension",

abstract = "Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.",

keywords = "Endothelin, Nitric oxide, Phosphodiesterase, Prostacyclin, Pulmonary hypertension, Pulmonary vasculature, Vasodilator",

author = "Steinhorn, {Robin H}",

year = "2012",

month = oct,

doi = "10.1016/j.pcl.2012.07.011",

language = "English (US)",

volume = "59",

pages = "1130--1146",

journal = "Pediatric Clinics of North America",

issn = "0031-3955",

publisher = "W.B. Saunders Ltd",

number = "5",

}

TY - JOUR

T1 - Pharmacotherapy for Pulmonary Hypertension

AU - Steinhorn, Robin H

PY - 2012/10

Y1 - 2012/10

N2 - Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

AB - Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

KW - Endothelin

KW - Nitric oxide

KW - Phosphodiesterase

KW - Prostacyclin

KW - Pulmonary hypertension

KW - Pulmonary vasculature

KW - Vasodilator

UR - http://www.scopus.com/inward/record.url?scp=84867070620&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867070620&partnerID=8YFLogxK

U2 - 10.1016/j.pcl.2012.07.011

DO - 10.1016/j.pcl.2012.07.011

M3 - Article

C2 - 23036248

AN - SCOPUS:84867070620

VL - 59

SP - 1130

EP - 1146

JO - Pediatric Clinics of North America

JF - Pediatric Clinics of North America

SN - 0031-3955

IS - 5

ER -

Pharmacotherapy for Pulmonary Hypertension

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this