Pharmacotherapy for Pulmonary Hypertension

Robin H Steinhorn

doi:10.1016/j.pcl.2012.07.011

Pharmacotherapy for Pulmonary Hypertension

Robin H Steinhorn

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

Original language	English (US)
Pages (from-to)	1130-1146
Number of pages	17
Journal	Pediatric Clinics of North America
Volume	59
Issue number	5
DOIs	https://doi.org/10.1016/j.pcl.2012.07.011
State	Published - Oct 2012
Externally published	Yes

Keywords

Endothelin
Nitric oxide
Phosphodiesterase
Prostacyclin
Pulmonary hypertension
Pulmonary vasculature
Vasodilator

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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keywords = "Endothelin, Nitric oxide, Phosphodiesterase, Prostacyclin, Pulmonary hypertension, Pulmonary vasculature, Vasodilator",

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AB - Pulmonary arterial hypertension is a serious disease with significant morbidity and mortality. Although it can occur idiopathically, it is more commonly associated with other cardiac or lung diseases. While most of the available therapies have been tested in adult populations and most therapies in children remain off-label, new reports and randomized trials are emerging that inform the treatment of pediatric populations. This review discusses currently available therapies for pediatric pulmonary hypertension, their biological rationales, and evidence for their clinical effectiveness.

KW - Endothelin

KW - Nitric oxide

KW - Phosphodiesterase

KW - Prostacyclin

KW - Pulmonary hypertension

KW - Pulmonary vasculature

KW - Vasodilator

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ER -

Pharmacotherapy for Pulmonary Hypertension

Abstract

Keywords

ASJC Scopus subject areas

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