Pharmacology of agents used in bone marrow transplant conditioning regimens

Valerie J. Wiebe, Brian R. Smith, Michael W. DeGregorio, Joel M. Rappeport

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Disease state, donor histocompatibility, effective immunosuppression, antineoplastic activity and creation of physiological hematopoietic space are all key determinants of succesful bone marrow transplantation (BMT). Preparative BMT regimens have evolved from the use of single fraction total body irradiation (TBI) to elaborate combinations of multidrugs and fractionated TBI regimens. Many of these newly developed conditioning regiments have increased engraftment rates and curative potential. The purpose of this review is to critically examine the pharmacologic behavior of the most commonly used agents in bone marrow transplantation conditioning regimens. The known immunosuppressive, antihematopoietic and antineoplastic properties of each agent are discussed. In addition, the pharmacokinetics and toxicity profiles are evaluated. A thorough understanding of the pharmacology of agents used in BMT may aid in the design of patient specific conditioning regimens.

Original languageEnglish (US)
Pages (from-to)241-270
Number of pages30
JournalCritical Reviews in Oncology and Hematology
Volume13
Issue number3
DOIs
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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