Pharmacological response of systemically derived focal epileptic lesions

M. P. Remler, K. Sigvardt, W. H. Marcussen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Focal epileptic lesions were made in rats by systemic focal epileptogenesis. In this method, a focal lesion of the blood-brain barrier (BBB) is produced by focal α irradiation followed by repeated systemic injection of a convulsant drug that cannot cross the normal BBB, resulting in a chronic epileptic focus. Changes in the spike frequency of these foci in response to various drugs was recorded. The controls, saline and chlorpromazine, produced no change. Phenytoin, phenobarbital, chlordiazepoxide, and valproic acid produced the expected decrease in spike frequency. Pentobarbital and diazapam produced a paradoxical increase in spike frequency.

Original languageEnglish (US)
Pages (from-to)671-677
Number of pages7
JournalEpilepsia
Volume27
Issue number6
StatePublished - 1986

Fingerprint

Blood-Brain Barrier
Pharmacology
Chlordiazepoxide
Convulsants
Chlorpromazine
Valproic Acid
Phenytoin
Pentobarbital
Phenobarbital
Pharmaceutical Preparations
Injections

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Remler, M. P., Sigvardt, K., & Marcussen, W. H. (1986). Pharmacological response of systemically derived focal epileptic lesions. Epilepsia, 27(6), 671-677.

Pharmacological response of systemically derived focal epileptic lesions. / Remler, M. P.; Sigvardt, K.; Marcussen, W. H.

In: Epilepsia, Vol. 27, No. 6, 1986, p. 671-677.

Research output: Contribution to journalArticle

Remler, MP, Sigvardt, K & Marcussen, WH 1986, 'Pharmacological response of systemically derived focal epileptic lesions', Epilepsia, vol. 27, no. 6, pp. 671-677.
Remler MP, Sigvardt K, Marcussen WH. Pharmacological response of systemically derived focal epileptic lesions. Epilepsia. 1986;27(6):671-677.
Remler, M. P. ; Sigvardt, K. ; Marcussen, W. H. / Pharmacological response of systemically derived focal epileptic lesions. In: Epilepsia. 1986 ; Vol. 27, No. 6. pp. 671-677.
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