Abstract
Focal epileptic lesions were made in rats by systemic focal epileptogenesis. In this method, a focal lesion of the blood-brain barrier (BBB) is produced by focal α irradiation followed by repeated systemic injection of a convulsant drug that cannot cross the normal BBB, resulting in a chronic epileptic focus. Changes in the spike frequency of these foci in response to various drugs was recorded. The controls, saline and chlorpromazine, produced no change. Phenytoin, phenobarbital, chlordiazepoxide, and valproic acid produced the expected decrease in spike frequency. Pentobarbital and diazapam produced a paradoxical increase in spike frequency.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 671-677 |
| Number of pages | 7 |
| Journal | Epilepsia |
| Volume | 27 |
| Issue number | 6 |
| State | Published - 1986 |
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ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
Cite this
Pharmacological response of systemically derived focal epileptic lesions. / Remler, M. P.; Sigvardt, K.; Marcussen, W. H.
In: Epilepsia, Vol. 27, No. 6, 1986, p. 671-677.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pharmacological response of systemically derived focal epileptic lesions
AU - Remler, M. P.
AU - Sigvardt, K.
AU - Marcussen, W. H.
PY - 1986
Y1 - 1986
N2 - Focal epileptic lesions were made in rats by systemic focal epileptogenesis. In this method, a focal lesion of the blood-brain barrier (BBB) is produced by focal α irradiation followed by repeated systemic injection of a convulsant drug that cannot cross the normal BBB, resulting in a chronic epileptic focus. Changes in the spike frequency of these foci in response to various drugs was recorded. The controls, saline and chlorpromazine, produced no change. Phenytoin, phenobarbital, chlordiazepoxide, and valproic acid produced the expected decrease in spike frequency. Pentobarbital and diazapam produced a paradoxical increase in spike frequency.
AB - Focal epileptic lesions were made in rats by systemic focal epileptogenesis. In this method, a focal lesion of the blood-brain barrier (BBB) is produced by focal α irradiation followed by repeated systemic injection of a convulsant drug that cannot cross the normal BBB, resulting in a chronic epileptic focus. Changes in the spike frequency of these foci in response to various drugs was recorded. The controls, saline and chlorpromazine, produced no change. Phenytoin, phenobarbital, chlordiazepoxide, and valproic acid produced the expected decrease in spike frequency. Pentobarbital and diazapam produced a paradoxical increase in spike frequency.
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UR - http://www.scopus.com/inward/citedby.url?scp=0022910350&partnerID=8YFLogxK
M3 - Article
VL - 27
SP - 671
EP - 677
JO - Epilepsia
JF - Epilepsia
SN - 0013-9580
IS - 6
ER -