Pharmacological regulation of the immune system

C. C. Chang, M. Naiki, G. M. Halpern, M. Eric Gershwin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Immunomodulators include any agent or substance that has an effect on the host immune system. These effects may be stimulatory, suppressive or regulatory. Many drugs, chemicals and microbial products have been identified as having specific as well as nonimmunostimulating properties. The first agent to be used clinically as an immunostimulating drug was Bacillus Calmeffe-Cuerin (BCC). Subsequently, other bacterial derivatives, including Corynebacterium parvum and bacterial lipopolysaccharides, were found to have stimulatory effects. Most research in immunostimulating agents has been done in cancer chemotherapy, where such compounds or preparations have been employed to (hopefully) restore chemotherapeutic agent-induced immunosuppression, and thus prevent the development of community-acquired or nosocomial infections. In contrast to immunostimulants, immunoregulators are traditionally defined as being capable of decreasing an abnormally elevated immune response, and therefore restore defective immune function. However, the differentiation between immunoregulators and immunostimulants is not always clearly defined, as the regulatory effects on the immune system of any particular drug may be multifaceted. Clearly, future research must be directed at defining the specific mechanisms of action of potential therapeutic drugs, and in developing improved molecules to ensure safety and efficacy in the clinical setting.

Original languageEnglish (US)
Pages (from-to)8-18
Number of pages11
JournalJournal of Investigational Allergology and Clinical Immunology
Volume3
Issue number1
StatePublished - 1993

Fingerprint

Immune System
Pharmacology
Immunologic Adjuvants
Pharmaceutical Preparations
Community-Acquired Infections
Propionibacterium acnes
Immunologic Factors
Cross Infection
Immunosuppression
Bacillus
Action Potentials
Lipopolysaccharides
Safety
Drug Therapy
Research
Neoplasms
Therapeutics

Keywords

  • allergic diseases
  • autoimmunity
  • immunomodulation
  • immunostimulation

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Pharmacological regulation of the immune system. / Chang, C. C.; Naiki, M.; Halpern, G. M.; Gershwin, M. Eric.

In: Journal of Investigational Allergology and Clinical Immunology, Vol. 3, No. 1, 1993, p. 8-18.

Research output: Contribution to journalArticle

@article{9d7f92fa9b69457d808f37ea620aedc6,
title = "Pharmacological regulation of the immune system",
abstract = "Immunomodulators include any agent or substance that has an effect on the host immune system. These effects may be stimulatory, suppressive or regulatory. Many drugs, chemicals and microbial products have been identified as having specific as well as nonimmunostimulating properties. The first agent to be used clinically as an immunostimulating drug was Bacillus Calmeffe-Cuerin (BCC). Subsequently, other bacterial derivatives, including Corynebacterium parvum and bacterial lipopolysaccharides, were found to have stimulatory effects. Most research in immunostimulating agents has been done in cancer chemotherapy, where such compounds or preparations have been employed to (hopefully) restore chemotherapeutic agent-induced immunosuppression, and thus prevent the development of community-acquired or nosocomial infections. In contrast to immunostimulants, immunoregulators are traditionally defined as being capable of decreasing an abnormally elevated immune response, and therefore restore defective immune function. However, the differentiation between immunoregulators and immunostimulants is not always clearly defined, as the regulatory effects on the immune system of any particular drug may be multifaceted. Clearly, future research must be directed at defining the specific mechanisms of action of potential therapeutic drugs, and in developing improved molecules to ensure safety and efficacy in the clinical setting.",
keywords = "allergic diseases, autoimmunity, immunomodulation, immunostimulation",
author = "Chang, {C. C.} and M. Naiki and Halpern, {G. M.} and Gershwin, {M. Eric}",
year = "1993",
language = "English (US)",
volume = "3",
pages = "8--18",
journal = "Journal of Investigational Allergology and Clinical Immunology",
issn = "1018-9068",
publisher = "Esmon",
number = "1",

}

TY - JOUR

T1 - Pharmacological regulation of the immune system

AU - Chang, C. C.

AU - Naiki, M.

AU - Halpern, G. M.

AU - Gershwin, M. Eric

PY - 1993

Y1 - 1993

N2 - Immunomodulators include any agent or substance that has an effect on the host immune system. These effects may be stimulatory, suppressive or regulatory. Many drugs, chemicals and microbial products have been identified as having specific as well as nonimmunostimulating properties. The first agent to be used clinically as an immunostimulating drug was Bacillus Calmeffe-Cuerin (BCC). Subsequently, other bacterial derivatives, including Corynebacterium parvum and bacterial lipopolysaccharides, were found to have stimulatory effects. Most research in immunostimulating agents has been done in cancer chemotherapy, where such compounds or preparations have been employed to (hopefully) restore chemotherapeutic agent-induced immunosuppression, and thus prevent the development of community-acquired or nosocomial infections. In contrast to immunostimulants, immunoregulators are traditionally defined as being capable of decreasing an abnormally elevated immune response, and therefore restore defective immune function. However, the differentiation between immunoregulators and immunostimulants is not always clearly defined, as the regulatory effects on the immune system of any particular drug may be multifaceted. Clearly, future research must be directed at defining the specific mechanisms of action of potential therapeutic drugs, and in developing improved molecules to ensure safety and efficacy in the clinical setting.

AB - Immunomodulators include any agent or substance that has an effect on the host immune system. These effects may be stimulatory, suppressive or regulatory. Many drugs, chemicals and microbial products have been identified as having specific as well as nonimmunostimulating properties. The first agent to be used clinically as an immunostimulating drug was Bacillus Calmeffe-Cuerin (BCC). Subsequently, other bacterial derivatives, including Corynebacterium parvum and bacterial lipopolysaccharides, were found to have stimulatory effects. Most research in immunostimulating agents has been done in cancer chemotherapy, where such compounds or preparations have been employed to (hopefully) restore chemotherapeutic agent-induced immunosuppression, and thus prevent the development of community-acquired or nosocomial infections. In contrast to immunostimulants, immunoregulators are traditionally defined as being capable of decreasing an abnormally elevated immune response, and therefore restore defective immune function. However, the differentiation between immunoregulators and immunostimulants is not always clearly defined, as the regulatory effects on the immune system of any particular drug may be multifaceted. Clearly, future research must be directed at defining the specific mechanisms of action of potential therapeutic drugs, and in developing improved molecules to ensure safety and efficacy in the clinical setting.

KW - allergic diseases

KW - autoimmunity

KW - immunomodulation

KW - immunostimulation

UR - http://www.scopus.com/inward/record.url?scp=0027278692&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027278692&partnerID=8YFLogxK

M3 - Article

C2 - 8281333

AN - SCOPUS:0027278692

VL - 3

SP - 8

EP - 18

JO - Journal of Investigational Allergology and Clinical Immunology

JF - Journal of Investigational Allergology and Clinical Immunology

SN - 1018-9068

IS - 1

ER -